Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases. Perspectives and therapeutic aspects.
Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases. Perspectives and therapeutic aspects.
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DOI：
10.15537/smj.2016.4.14768
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发表时间：
2016-04
影响因子：
1.6
通讯作者：
Sibilia J
中科院分区：
文献类型：
--
作者：
Harifi G;Sibilia J
众所周知，血小板在血管平衡中的作用，可能在炎症和免疫调节中发挥重要作用。关于血小板在炎症性关节炎和自身免疫性疾病中的致病作用的大量数据出现，表明凝血和炎症系统之间存在串扰。激活后，血小板释放促炎血小板微粒，与白细胞相互作用，导致类风湿关节炎的关节和全身炎症。免疫复合物激活血小板激活树突状细胞，促进干扰素α的分泌，这在系统性红斑狼疮的发展中起关键作用。在这篇综述中，我们讨论了血小板在炎性关节炎和各种自身免疫性疾病（如类风湿关节炎、系统性红斑狼疮和系统性硬化症）的病理生理学中的作用的最新数据。
Well-recognized for their role in vascular homoeostasis, platelets may play a major role in inflammation and immunomodulation. Substantial data are emerging on the pathogenic involvement of platelets in inflammatory arthritis and autoimmune diseases, indicating the existence of crosstalk between the coagulation and inflammation system. Upon activation, platelets release pro-inflammatory platelets microparticles, which interact with leucocytes leading to joint and systemic inflammation in rheumatoid arthritis. Platelets activation by immune complexes activate dendritic cells promoting the secretion of interferon alpha, which has a key role in the development of systemic lupus erythematous. In this review, we discuss the current data on the role of platelets in the pathophysiology of inflammatory arthritis and various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis.