Role and regulation of kinesin-8 motors through the cell cycle.
Role and regulation of kinesin-8 motors through the cell cycle.
复制标题
DOI：
10.1007/s11693-014-9140-z
复制
发表时间：
2014-09-01
期刊：
影响因子：
--
通讯作者：
Millar, Jonathan B A
中科院分区：
文献类型：
--
作者：
Messin, Liam J;Millar, Jonathan B A
在真核细胞周期中，驱动蛋白-8运动家族的成员在控制微管长度方面起着核心作用。驱动蛋白-8的失活导致间期细胞极性、星形细胞和有丝分裂纺锤体长度、中期染色体排列、后期开始的时间和染色体分离的准确性的缺陷。虽然驱动蛋白-8分子影响微管动力学的生物物理机制已经在各种物种中进行了广泛的研究，但尚未形成共识。其中一个原因可能是驱动蛋白-8家族的一些成员可以与其他微管相关蛋白、细胞周期调节蛋白和其他驱动蛋白家族成员结合。在这篇综述中，我们考虑如何细胞周期特异性修饰及其与其他调节蛋白的关联可能会调节驱动蛋白-8的功能，使其能够作为微管动力学的主调节器。
Members of the kinesin-8 motor family play a central role in controlling microtubule length throughout the eukaryotic cell cycle. Inactivation of kinesin-8 causes defects in cell polarity during interphase and astral and mitotic spindle length, metaphase chromosome alignment, timing of anaphase onset and accuracy of chromosome segregation. Although the biophysical mechanism by which kinesin-8 molecules influence microtubule dynamics has been studied extensively in a variety of species, a consensus view has yet to emerge. One reason for this might be that some members of the kinesin-8 family can associate to other microtubule-associated proteins, cell cycle regulatory proteins and other kinesin family members. In this review we consider how cell cycle specific modification and its association to other regulatory proteins may modulate the function of kinesin-8 to enable it to function as a master regulator of microtubule dynamics.