The transcription factor PLZF directs the effector program of the NKT cell lineage.
The transcription factor PLZF directs the effector program of the NKT cell lineage.
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转录因子 PLZF 指导 NKT 细胞谱系的效应程序。
DOI：
10.1016/j.immuni.2008.07.011
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发表时间：
2008-09-19
期刊：
影响因子：
32.4
通讯作者：
Bendelac, Albert
中科院分区：
文献类型：
--
作者：
Savage, Adam K.;Constantinides, Michael G.;Han, Jin;Picard, Damien;Martin, Emmanuel;Li, Bofeng;Lantz, Olivier;Bendelac, Albert
CD1D限制性NKT细胞发育的转录控制仍然难以捉摸。 （TH-POK，ZBTB7B）完全特异性地是CD1D限制的NKT细胞和人类MR1特异性MAIT细胞。 NKT细胞前体和PLZF缺陷的NKT细胞无法经历胸膜膨胀和效应子分化，而效应子分化则保留了幼稚的表型，并将其定向到淋巴结。效应子分化并迁移到非淋巴组织。在胸腺发育过程中指导其先天效应子分化。
The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger; Zbtb16), a member of the BTB/POZ-ZF family of transcription factors which includes the CD4 lineage-specific c-Krox (Th-POK, Zbtb7b), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells. PLZF was induced immediately after positive selection of NKT cell precursors and PLZF-deficient NKT cells failed to undergo the intrathymic expansion and effector differentiation that characterize their lineage. Instead, they preserved a naïve phenotype and were directed to lymph nodes. Conversely, transgenic expression of PLZF induced CD4 thymocytes to acquire effector differentiation and migrate to non-lymphoid tissues. We suggest that PLZF is a transcriptional signature of NKT cells that directs their innate-like effector differentiation during thymic development.
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影响因子：
64.8
作者：
He, X;He, X;Kappes, DJ
通讯作者：
Kappes, DJ
影响因子：
30.5
作者：
Intlekofer, AM;Takemoto, N;Reiner, SL
通讯作者：
Reiner, SL
影响因子：
15.3
作者：
Benlagha, K;Weiss, A;Beavis, A;Teyton, L;Bendelac, A
通讯作者：
Bendelac, A
DOI：
10.1084/jem.20050456
发表时间：
2005-08-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Benlagha K;Wei DG;Veiga J;Teyton L;Bendelac A
通讯作者：
Bendelac A
影响因子：
32.4
作者：
Egawa, T;Eberl, G;Littman, DR
通讯作者：
Littman, DR