Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer
Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer
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DOI：
10.1101/cshperspect.a003202
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发表时间：
2010-10-01
影响因子：
7.2
通讯作者：
Streuli, Charles H.
中科院分区：
文献类型：
--
作者：
Muschler, John;Streuli, Charles H.
乳腺是一个器官，它给年轻人带来生命，但同时也对母亲构成最大的威胁之一。了解组织如何发育和功能对于确定其控制机制如何在乳腺癌中分解至关重要。在这里，我们认为，乳腺上皮细胞和它们的细胞外基质（ECM）之间的相互作用是至关重要的组织的发育和功能。目前治疗乳腺癌的策略利用了我们对乳腺发育的内分泌调节以及基质-上皮相互作用的新作用的知识（图1）。此外，关注细胞-基质相互作用产生的微环境影响将为治疗干预开辟新的机会。我们认为，最终针对内分泌，生长因子和细胞-基质相互作用的三管齐下的方法将提供治愈疾病的最佳机会。
The mammary gland is an organ that at once gives life to the young, but at the same time poses one of the greatest threats to the mother. Understanding how the tissue develops and functions is of pressing importance in determining how its control mechanisms break down in breast cancer. Here we argue that the interactions between mammary epithelial cells and their extracellular matrix (ECM) are crucial in the development and function of the tissue. Current strategies for treating breast cancer take advantage of our knowledge of the endocrine regulation of breast development, and the emerging role of stromal-epithelial interactions (Fig. 1). Focusing, in addition, on the microenvironmental influences that arise from cell-matrix interactions will open new opportunities for therapeutic intervention. We suggest that ultimately a three-pronged approach targeting endocrine, growth factor, and cell-matrix interactions will provide the best chance of curing the disease.