The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
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DOI：
10.1016/j.ceb.2008.10.001
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发表时间：
2008-12
影响因子：
7.5
通讯作者：
Guan KL
中科院分区：
文献类型：
--
作者：
Zhao B;Lei QY;Guan KL
器官大小的控制是一个基本的生物学问题。在过去的几年里，Hippo信号通路已经被描绘出来，并被证明在果蝇和哺乳动物的器官大小控制中起着关键作用。在Hippo通路下游作用的是Yki/YAP/TAZ转录共激活因子。在哺乳动物细胞中，Hippo通路激酶级联通过磷酸化和促进其细胞质定位来抑制YAP及其平行TAZ。TEAD家族转录因子最近被确定为进化保守的YAP生物学功能的关键介质。yap是一种候选致癌基因，Hippo通路的其他几个成分是肿瘤抑制因子。Hippo通路的失调导致癌细胞中接触抑制的丧失。因此，Hippo-YAP通路连接了器官大小和肿瘤发生的调节。
The control of organ size is a basic biological question. In the last several years, the Hippo signaling pathway has been delineated and shown to be critical in control of organ size in both Drosophila and mammals. Acting downstream of the Hippo pathway is the Yki/YAP/TAZ transcription co-activators. In mammalian cells, the Hippo pathway kinase cascade inhibits YAP and its paralog TAZ by phosphorylation and promotion of their cytoplasmic localization. The TEAD family transcription factors have recently been identified as evolutionarily conserved key mediators of YAP biological functions. yap is a candidate oncogene, and several other components of the Hippo pathway are tumor suppressors. Dysregulation of the Hippo pathway contributes to the loss of contact inhibition observed in cancer cells. Therefore, the Hippo-YAP pathway connects the regulation of organ size and tumorigenesis.
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影响因子：
4.6
作者：
Kango-Singh, M;Nolo, R;Halder, G
通讯作者：
Halder, G
DOI：
10.1073/pnas.0605266104
发表时间：
2007-01-30
影响因子：
11.1
作者：
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影响因子：
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作者：
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通讯作者：
Yaffe, MB