Parenting and adolescent antisocial behavior and depression - Evidence of genotype x parenting environment interaction
Parenting and adolescent antisocial behavior and depression - Evidence of genotype x parenting environment interaction
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DOI：
10.1001/archpsyc.64.4.457
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发表时间：
2007-04-01
影响因子：
--
通讯作者：
Hetherington, E. Mavis
中科院分区：
文献类型：
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作者：
Feinberg, Mark E.;Button, Tanya M. M.;Hetherington, E. Mavis
背景：对于影响青少年精神症状和疾病的基因型和可塑性危险因素之间的相互作用，人们知之甚少。有关这些过程的信息对于设计预防精神疾病的计划至关重要。目的：评估潜在遗传因素和测量的亲子关系在预测青少年反社会行为和抑郁症方面是否相互作用（G x E）。设计：我们通过基因设计来描述青少年反社会行为和抑郁症的风险。我们使用了家庭问卷调查和青少年结果和环境调节因素（养育）的观察措施，以及潜在变量行为遗传分析模型。设置：从随机数字拨号和全国市场小组中收集的全国分布的样本。参与者：共有 720 个至少有 2 个孩子（9 至 18 岁）的家庭，按遗传相关性分层（同卵双胞胎和异卵双胞胎、非离婚家庭和继家庭中的亲生兄弟姐妹、继家庭中的同父异母兄弟姐妹和无血缘关系的兄弟姐妹）。主要结果指标：反社会行为和抑郁症状。结果：基因型与父母的消极情绪和低热情之间存在相互作用，预测总体反社会行为，以及攻击性和非攻击性的反社会行为，但不影响抑郁症。当养育方式更加消极或不那么热情时，遗传对青少年反社会行为的影响更大。基因型-环境相关性在分析中被部分排除，因此没有考虑到结果。结论：本研究表明，在仔细测量和适当分析方法的基础上，在规范范围内持续测量养育方式可以调节基因型对反社会行为的影响。
Background: Little is known about the interplay of genotypes and malleable risk factors in influencing adolescent psychiatric symptoms and disorders. Information on these processes is crucial in designing programs for the prevention of psychiatric disorders. Objective: To assess whether latent genetic factors and measured parent-child relationships interact (G x E) in predicting adolescent antisocial behavior and depression. Design: We characterized risk of antisocial behavior and depression in adolescents by means of a genetically informed design. We used in-home questionnaire and observational measures of adolescent outcomes and environmental moderators (parenting), and a latent variable behavior genetic analytic model. Setting: A nationally distributed sample recruited from random-digit dialing and national market panels. Participants: A total of 720 families with at least 2 children, 9 through 18 years old, stratified by genetic relatedness (monozygotic and dizygotic twins, full biological siblings in nondivorced and stepfamilies, and half-siblings and biologically unrelated siblings in stepfamilies). Main Outcome Measures: Antisocial behavior and depressive symptoms. Results: There was an interaction of genotype and both parental negativity and low warmth predicting overall antisocial behavior, as well as aggressive and nonaggressive forms of antisocial behavior, but not depression. Genetic influence was greater for adolescent antisocial behavior when parenting was more negative or less warm. Genotype-environment correlation was partialled out in the analysis and thus did not account for the results. Conclusion: This study demonstrates, on the basis of careful measurement and appropriate analytic methods, that a continuous measure of parenting in the normative range moderates the influence of genotype on antisocial behavior.