Reversal of right-ventricular dysfunction in pulmonary arterial hypertension following sildenafil therapy.
Reversal of right-ventricular dysfunction in pulmonary arterial hypertension following sildenafil therapy.
复制标题
西地那非治疗后肺动脉高压右心室功能障碍的逆转。
DOI：
10.1093/eurheartj/ehv036
复制
发表时间：
2015
影响因子：
39.3
通讯作者：
Farzaneh-Far,Afshin
中科院分区：
文献类型：
--
作者：
Romano,Simone;Chung,Jaehoon;Farzaneh-Far,Afshin
一位42岁女性，因长期服用泼尼松及家庭氧疗而患上慢性肺结节病，被转诊至心脏科，出现劳力性胸闷症状。体格检查显示明显的右室(RV)隆起和第二心音(P2)响亮。血浆B型利钠肽(BNP)水平升高至183pg/ml。经胸超声心动图提示严重的右室增大和收缩功能障碍，估计肺收缩压为60毫米汞柱。心脏磁共振成像证实无明显瓣膜病变的严重右室增大(RVEDV/218mL)和收缩功能障碍(RVEF/27%)
A 42-year-old-woman with known chronic pulmonarysarcoidosis on long-term prednisone and home-oxygen therapy was referred to cardiology with symptoms of exertional chest tightness. Physical examination was notable for a palpable right-ventricular (RV) heave and a loud second heart sound (P2). Plasma B-natriuretic peptide (BNP) levels were elevated at 183pg/mL. Transthoracic-echocardiography was suggestive of severe RV enlargement and systolic dysfunction with an estimated pulmonary systolic pressure of 60mmHg. Cardiac magnetic resonance imaging confirmed severe RV enlargement (RVEDV ¼ 218 mL) and systolic dysfunction (RVEF ¼ 27%) without significant valvular disease