Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age
Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age
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DOI：
10.1016/s8756-3282(00)00236-2
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发表时间：
2000-04-01
期刊：
影响因子：
4.1
通讯作者：
Fyhrie, DP
中科院分区：
文献类型：
--
作者：
Vashishth, D;Verborgt, O;Fyhrie, DP
尽管骨细胞的理想位置，感觉到当地的环境，从而影响骨重建，骨细胞在骨的功能仍然存在争议。在这项研究中，对男性和女性股骨中段皮质骨进行组织形态计量学检查，以确定骨重建反应（由组织孔隙度和损伤累积指示）是否与骨细胞腔隙密度相关（单位骨面积的骨细胞陷窝数量），结果支持骨细胞网络的感觉作用，因为人皮质骨中骨细胞陷窝密度的下降与骨细胞的生长有关。微裂纹的积累和孔隙度随时间的增加。孔隙率和微裂纹密度呈指数增加，骨细胞腔隙密度下降，表明一定的最低数量的骨细胞是必不可少的“操作”网络。在骨细胞陷窝密度与年龄、孔隙度或微裂纹密度的关系中没有发现性别相关的差异。骨细胞陷窝密度的变异系数随年龄增长呈线性增加，表明衰老骨组织的特征是骨细胞空间组织异质性增加。骨细胞陷窝密度、孔隙率和微裂纹密度在供体群体中表现出相同的指数概率密度分布，表明它们受到类似生物现象的调节。(Bone 26：375-380; 2000）（C）Elsevier Science Inc. All rights reserved.
Despite osteocytes' ideal position to sense the local environment and thereby influence bone remodeling, the function of osteocytes in bone remains controversial. In this study, histomorphometric examination of male and female femoral middiaphyseal cortical bone was conducted to determine if bone's remodeling response, indicated by tissue porosity and accumulation of damage, is associated with osteocyte lacunar density (number of osteocyte lacunae per bone area), The results support the sensory role of the osteocyte network as the decline in osteocyte lacunar density in human cortical bone is associated with the accumulation of microcracks and increase in porosity with age. Porosity and microcrack density increased exponentially with a decline in osteocyte lacunar density indicating that a certain minimum number of osteocytes is essential for an "operational" network. No gender-related differences were found in the relationship of osteocyte lacunar density to age, porosity, or microcrack density. The coefficient of variation of osteocyte lacunar density increased linearly with age, indicating that aging bone tissue is characterized by increased heterogeneity in the spatial organization of osteocytes. Osteocyte lacunar density, porosity, and microcrack density exhibited the same exponential probability density distribution in the donor population, indicating their regulation by similar biological phenomena. (Bone 26:375-380; 2000) (C) 2000 by Elsevier Science Inc. All rights reserved.