A TWIN STUDY OF GENETIC AND ENVIRONMENTAL CONTRIBUTIONS TO LIABILITY FOR POSTTRAUMATIC STRESS SYMPTOMS
A TWIN STUDY OF GENETIC AND ENVIRONMENTAL CONTRIBUTIONS TO LIABILITY FOR POSTTRAUMATIC STRESS SYMPTOMS
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DOI：
10.1001/archpsyc.1993.01820160019002
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发表时间：
1993-04-01
影响因子：
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通讯作者：
NOWAK, J
中科院分区：
文献类型：
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作者：
TRUE, WR;RICE, J;NOWAK, J
我们研究了4042对越战老兵同卵和异卵男性双胞胎，以确定遗传、共享环境和独特环境对15种自我报告的创伤后应激障碍症状的易感性的影响，这些症状包括重新经历创伤、避免与创伤相关的刺激和增加唤醒。定量遗传分析表明，遗传对所有症状的责任有实质性影响。症状的再体验集群和一个症状的回避和麻木集群与战斗暴露，和单卵对战斗暴露比双卵对更高度一致。通过拟合一个双变量遗传模型，我们发现，有显着的遗传影响的症状的责任，即使在调整后的差异，战斗暴露;遗传因素占13%至30%的变异的责任症状的再体验集群，30%至34%的症状的回避集群，和28%至32%的症状的觉醒集群。没有证据表明，共同的环境有助于创伤后应激障碍症状的发展。
We studied 4042 Vietnam era veteran monozygotic and dizygotic male twin pairs to determine the effects of heredity, shared environment, and unique environment on the liability for 15 self-reported posttraumatic stress disorder symptoms included in the symptom categories of reexperiencing the trauma, avoidance of stimuli related to the trauma, and increased arousal. Ouantitative genetic analysis reveals that inheritance has a substantial influence on liability for all symptoms. Symptoms in the reexperiencing cluster and one symptom in the avoidance and numbing cluster are strongly associated with combat exposure, and monozygotic pairs are more highly concordant for combat exposure than dizygotic pairs. By fitting a bivariate genetic model, we show that there are significant genetic influences on symptom liability, even after adjusting for differences in combat exposure; genetic factors account for 13% to 30% of the variance in liability for symptoms in the reexperiencing cluster, 30% to 34% for symptoms in the avoidance cluster, and 28% to 32% for symptoms in the arousal cluster. There is no evidence that shared environment contributes to the development of posttraumatic stress disorder symptoms.