Renal Cancer Stem Cells: Characterization and Targeted Therapies.
Renal Cancer Stem Cells: Characterization and Targeted Therapies.
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DOI：
10.1155/2016/8342625
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发表时间：
2016
影响因子：
4.3
通讯作者：
Romagnani P
中科院分区：
文献类型：
--
作者：
Peired AJ;Sisti A;Romagnani P
肾细胞癌（Renal cell carcinoma，RCC）是西方国家常见的恶性肿瘤之一。肿瘤是异质性的，并且由分化的癌细胞、基质细胞和癌症干细胞（CSC）组成。CSC具有两个主要特性：自我更新和增殖。此外，一旦移植到免疫缺陷小鼠体内，它们可以产生新的肿瘤。已经描述了几种方法来鉴定它们，通过细胞标志物的表达，功能测定，或两者的组合。由于CSC参与了对放射性和化学疗法的抗性机制，已经提出了几种新的策略来直接靶向RCC中的CSC。一种方法促使CSC分化为对常规治疗敏感的癌细胞，而另一种方法则提出选择性地根除它们。一系列旨在消除CSC的创新疗法已被设计用于治疗其他类型的癌症，尚未在RCC上进行实验，但它们显示出自己的前景。总之，CSC在癌发生中是一个重要的参与者，并代表了RCC患者治疗的有效靶点。
Renal cell carcinoma (RCC) is a major neoplasm with high incidence in western countries. Tumors are heterogeneous and are composed of differentiated cancer cells, stromal cells, and cancer stem cells (CSCs). CSCs possess two main properties: self-renewal and proliferation. Additionally, they can generate new tumors once transplanted into immunodeficient mice. Several approaches have been described to identify them, through the expression of cell markers, functional assays, or a combination of both. As CSCs are involved in the resistance mechanisms to radio- and chemotherapies, several new strategies have been proposed to directly target CSCs in RCC. One approach drives CSCs to differentiate into cancer cells sensitive to conventional treatments, while the other proposes to eradicate them selectively. A series of innovative therapies aiming at eliminating CSCs have been designed to treat other types of cancer and have not been experimented with on RCC yet, but they reveal themselves to be promising. In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients.