Mild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents
Mild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents
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DOI：
10.1021/ol501087m
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发表时间：
2014-05-02
期刊：
影响因子：
5.2
通讯作者：
Hu, Xile
中科院分区：
文献类型：
--
作者：
Cheung, Chi Wai;Ren, Peng;Hu, Xile
提出了一种铁催化未活化的仲烷基溴和碘化物与炔基格氏试剂在室温下交叉偶联的简便方法。可以容忍广泛的仲烷基卤化物和末端炔烃，以便以良好的产率提供取代的炔烃。对反应方案稍作修改也允许与各种伯烷基卤化物交叉偶联。
A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of primary alkyl halides.