Nucleophilic attack of intramolecular hydroxyl groups on electron-rich aromatics using hypervalent iodine(III) oxidation
Nucleophilic attack of intramolecular hydroxyl groups on electron-rich aromatics using hypervalent iodine(III) oxidation
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DOI：
10.1016/j.tet.2007.02.118
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发表时间：
2007-05-07
期刊：
影响因子：
2.1
通讯作者：
Kita, Yasuyuki
中科院分区：
文献类型：
--
作者：
Hata, Kayoko;Hamamoto, Hiromi;Kita, Yasuyuki
利用高价碘试剂二（三氟乙酸）苯基碘（PIFA）介导的富电子芳烃与芳香阳离子自由基中间体的氧化亲核取代反应，直接进行芳香碳氧键形成反应，发展了一种简单新颖的苯并二氢吡喃衍生物的合成方法.作为该方法的延伸，还实现了对螺二烯酮衍生物的容易获得。(C)2007爱思唯尔有限公司保留所有权利。
The hypervalent iodine(III) reagent, phenyliodine bis(trifluoroacetate) (PIFA)-mediated oxidative nucleophilic substitution of electron-rich aromatics involving aromatic cation radical intermediates was utilized in the direct aromatic carbon-oxygen bond formation reaction, and a novel and simple synthetic method for chroman derivatives was developed. As an extension of this methodology, a facile access to spirodienone derivatives was also achieved. (C) 2007 Elsevier Ltd. All rights reserved.