Gestational weight gain, early pregnancy maternal adiposity distribution, and maternal hyperglycemia.
Gestational weight gain, early pregnancy maternal adiposity distribution, and maternal hyperglycemia.
复制标题
妊娠期体重增加、妊娠早期母亲肥胖分布和母亲高血糖。
DOI：
10.1007/s10995-013-1361-3
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发表时间：
2014
影响因子：
2.3
通讯作者：
Bodnar,LisaM
中科院分区：
文献类型：
--
作者：
Tomedi,LauraE;Simhan,HyagrivN;Chang,Chung-ChouH;McTigue,KathleenM;Bodnar,LisaM
To estimate the effects of gestational weight gain (GWG), central adiposity and subcutaneous fat on maternal post-load glucose concentration, pregnant women [n = 413, 62 % black, 57 % with pregravid body mass index (BMI) ≥25] enrolled in a cohort study at ≤13 weeks gestation. GWG was abstracted from medical records. In a sub-sample of women (n = 214), waist circumference (WC), and biceps and triceps skinfold thicknesses were measured at enrollment. At 24–28 weeks gestation, post-load glucose concentration was measured using a 50-g 1-h oral glucose tolerance test. After adjustment for pre-pregnancy BMI, age, parity, race/ethnicity, smoking, marital status, annual family income, education, family history of diabetes, and gestational age of GDM screening, each 0.3-kg/week increase in weight in the first trimester was associated with a 2.2 (95 % CI 0.1, 4.3)-mg/dl increase in glucose concentration. Each 8.6-mm increase in biceps skinfold thickness and each 11.7-mm increase in triceps skinfold thickness was associated with 4.3 (95 % CI 0.2, 8.5)-mg/dl increase in maternal glucose, independent of BMI and other confounders. Neither GWG in the second trimester nor WC at ≤13 weeks was significantly associated with glucose concentration after confounder adjustment. Independent of pre-pregnancy BMI, high early pregnancy GWG and maternal subcutaneous body fat may be positively associated with maternal glucose concentrations at 24–28 weeks.
