Ultrastructural evidence for increased contact between astrocytes and synapses in rats reared in a complex environment
Ultrastructural evidence for increased contact between astrocytes and synapses in rats reared in a complex environment
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DOI：
10.1006/nlme.1996.0005
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发表时间：
1996-01-01
影响因子：
2.7
通讯作者：
Greenough, WT
中科院分区：
文献类型：
--
作者：
Jones, TA;Greenough, WT
与饲养在标准实验室笼子中的动物相比，在复杂环境中断奶饲养的大鼠在视觉皮质中每个神经元的突触数量增加。先前的研究表明，经验依赖的突触变化可能与星形胶质细胞的变化相协调。本研究使用电子显微镜观察了在复杂环境(EC)或标准实验室笼子中饲养的大鼠视皮层星形胶质细胞的过程，无论是单独饲养(IC)还是成对饲养(社交条件，SC)。星形胶质细胞膜直接与突触元件结合的表面密度的测量表明，EC大鼠的星形细胞突起与视觉皮质内的突触元件的接触比SC和IC动物更多。相反，其他星形细胞大小变量显示单位组织体积的星形细胞突起没有显著变化。先前的研究表明，这些受试者的突触密度没有显著差异。星形胶质细胞和突触之间接触的特殊增加表明星形胶质细胞参与突触活动的经验相关的增强。(C)1996年学术出版社。
Rats raised from weaning in a complex environment have an increased number of synapses per neuron in the visual cortex in comparison to animals housed in standard laboratory cages. Previous research has suggested that experience-dependent synaptic changes may be coordinated with changes in astrocytes. The present study used electron microscopy to examine astrocytic processes in the visual cortex of rats raised in a complex environment (EC) or in standard laboratory cages, either individually (IC) or in pairs (social condition, SC). Measurements of the surface density of astrocytic membrane in direct apposition to synaptic elements revealed that astrocytic processes have increased contact with synaptic elements within the visual cortex of EC rats in comparison to SC and IC animals. In contrast, other astrocytic size variables revealed no significant change in astrocytic processes per unit volume of tissue. Previous work has indicated no significant differences in synaptic density in these subjects. The specific increase in the contact between astrocytes and synapses suggests an experience-related enhancement of the astrocytic involvement in synaptic activity. (C) 1996 Academic Press, Inc.