Complementary Synthetic Approaches to Constitutionally Diverse N-Aminoalkylated Isoindolinones: Application to the Synthesis of Falipamil and 5-HT1A Receptor Ligand Analogues
Complementary Synthetic Approaches to Constitutionally Diverse N-Aminoalkylated Isoindolinones: Application to the Synthesis of Falipamil and 5-HT1A Receptor Ligand Analogues
复制标题
DOI：
10.1055/s-0028-1088048
复制
发表时间：
2009-06-03
影响因子：
2.6
通讯作者：
Grandclaudon, Pierre
中科院分区：
文献类型：
--
作者：
Lorion, Magali;Couture, Axel;Grandclaudon, Pierre
不同的合成方法的阐述聚和双取代的异吲哚啉酮尾部与组成不同的氨基烷基化链已被开发。关键步骤是基于配备有羟烷基附件的异吲哚啉酮模板的初步组装。随后的末端羟基官能团的操作提供了目标化合物和这些方法的合成效用已被强调的心动过缓剂falipamil和5-HT 1A受体配体类似物的合成。
Different synthetic approaches for the elaboration of poly and diversely substituted isoindolinones tailed with constitutionally diverse aminoalkylated chains have been developed. The key step is based Upon the preliminary assembly of the isoindolinone template equipped with hydroxyalkyl appendages. Subsequent manipulation of the terminal hydroxy Functionality afforded the targeted compounds and the synthetic utility of these approaches has been emphasized by the synthesis of the bradycardic agent falipamil and 5-HT1A receptor ligand analogues.