Morphological changes in the triads and sarcoplasmic reticulum of rat slow and fast muscle fibres following denervation and immobilization
Morphological changes in the triads and sarcoplasmic reticulum of rat slow and fast muscle fibres following denervation and immobilization
复制标题
去神经和固定后大鼠慢肌纤维和快肌纤维三联体和肌浆网的形态变化
DOI：
10.1007/bf00123356
复制
发表时间：
1996
影响因子：
2.7
通讯作者：
T. Yoshioka
中科院分区：
文献类型：
--
作者：
H. Takekura;N. Kasuga;Kohji Kitada;T. Yoshioka
我们观察了大鼠比目鱼肌和指长伸肌在去神经和制动两种情况下参与兴奋-收缩偶联的膜系统(肌浆网、横管和三联体)的形态特征。固定部位：背侧最大屈肌(比目鱼肌伸展、趾长伸肌缩短)、足底最大屈肌(比目鱼肌缩短、指长伸肌伸缩)、背屈与足底屈肌中间。在这两种废弃条件下，膜系统的排列都是无序的。横管网络明显增多，三联体明显多于正常纤维，失神经和制动后常出现五行和七行结构(即两个或三个横管单元与肌浆网终池的三个或四个单元的近似)。去神经和固定对膜系统的影响最显著的区别是出现五倍体和七倍体的时间。失神经支配的肌纤维(失神经支配后1周)比固定的(制动后3或4周)肌纤维出现的时间要早得多。另一方面，五分肌和七分肌的频率与纤维类型(指长伸肌明显更高)和萎缩程度明显相关。不同腿位制动对膜系统的影响不同，但对于神经营养因子(S)，其对膜系统的影响受肌节长度的影响，在废弃骨骼肌纤维中，神经营养因子(S)和肌肉活性并不总是形成新的膜系统所必需的。
SummaryWe observed the morphological features of the membrane systems (sarcoplasmic reticulum, transverse tubules and triads) involved with the excitation-contraction coupling in rat soleus and extensor digitorum longus muscle following two disuse protocols: denervation and immobilization. The immobilized positions were: maximum dorsal flexor (soleus were stretched and extensor digitorum longus were shortened), maximum plantar flexor (soleus were shortened and extensor digitorum longus were stretched), and midway between the dorsal flexor and plantar flexor. The arrangement of the membrane systems was disordered following both disuse conditions. Increases in transverse tubule network were apparent; there were clearly more triads than in normal fibres, and pentadic and heptadic structures (i.e., a close approximation of two or three transverse tubule elements with three or four elements of terminal cisternae of sarcoplasmic reticulum) were frequently appeared following both denervation and immobilization. The most notable difference between the influence of denervation and immobilization on the membrane systems is the time at which the pentads and heptads appeared. They appeared much earlier (1 week after denervation) in denervated than in immobilized (3 or 4 weeks after immobilization) muscle fibres. On the other hand, the frequency of pentads and heptads is clearly related to the fibre type (significantly higher in extensor digitorum longus) and to extent of atrophy. The different influences of immobilization in each leg position suggest that disuse, but with neurotrophic factor(s), influences on the membrane systems were affected by sarcomere length, and the neurotrophic factor(s) and muscle activity were not always necessary to form mew membrane systems in disuse skeletal muscle fibres.
去神经骨骼肌中肌浆网 Ca2 泵的表达。
DOI：
10.1152/ajpcell.1994.267.2.c617
发表时间：
1994
期刊：
The American journal of physiology
影响因子：
--
作者：
Schulte,L;Peters,D;Taylor,J;Navarro,J;Kandarian,S
通讯作者：
Kandarian,S