Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
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DOI：
10.1016/s0028-3908(98)00199-3
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发表时间：
1999-02-01
影响因子：
4.7
通讯作者：
Bernardi, G
中科院分区：
文献类型：
--
作者：
Calabresi, P;Centonze, D;Bernardi, G
我们研究了内源性乙酰胆碱（Ach）在皮质纹状体长时程增强（LTP）中的作用。毒蕈碱受体拮抗剂东莨菪碱和哌仑西平完全防止诱导的LTP，这表明Mi样毒蕈碱受体的激活是在这种形式的突触可塑性的调节阶段的一个至关重要的事件。(C)1999 Elsevier Science Ltd.保留所有权利。
We studied the role of endogenous acetylcholine (Ach) in corticostriatal long-term potentiation (LTP). The muscarinic receptor antagonists scopolamine and pirenzepine fully prevented the induction of LTP suggesting that the activation of Mi-like muscarinic receptors is a crucial event in the conditioning phase of this form of synaptic plasticity. (C) 1999 Elsevier Science Ltd. All rights reserved.