Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans
Remnant Cholesterol Elicits Arterial Wall Inflammation and a Multilevel Cellular Immune Response in Humans
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DOI：
10.1161/atvbaha.116.308834
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发表时间：
2017-05-01
影响因子：
8.7
通讯作者：
Kroon, Jeffrey
中科院分区：
文献类型：
--
作者：
Moens, Sophie J. Bernelot;Verweij, Simone L.;Kroon, Jeffrey
孟德尔随机研究揭示了残余胆固醇在心血管疾病中的因果作用。残留颗粒积聚在动脉壁中，可能传播局部和全身炎症。我们评估了家族性异常β脂蛋白血症（FD）患者残余胆固醇对动脉壁炎症、循环单核细胞和骨髓的影响。方法和结果：使用F-18-FDG PET/CT测量动脉壁炎症和骨髓活性。单核细胞表型用流式细胞术评估。残基水平和造血活性之间的相关性在CGPS（哥本哈根一般人群研究）中得到验证。我们发现FD患者（n=17，年龄60 ± 8岁，残余胆固醇：3.26 [2.07-5.71]）动脉壁的F-18-FDG摄取比对照组（n= 17，年龄61 ± 8岁，残余胆固醇：0.29 [0.27-0.40]; P
Objective-Mendelian randomization studies revealed a causal role for remnant cholesterol in cardiovascular disease. Remnant particles accumulate in the arterial wall, potentially propagating local and systemic inflammation. We evaluated the impact of remnant cholesterol on arterial wall inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD).Approach and Results-Arterial wall inflammation and bone marrow activity were measured using F-18-FDG PET/CT. Monocyte phenotype was assessed with flow cytometry. The correlation between remnant levels and hematopoietic activity was validated in the CGPS (Copenhagen General Population Study). We found a 1.2-fold increase of F-18-FDG uptake in the arterial wall in patients with FD (n=17, age 60 +/- 8 years, remnant cholesterol: 3.26 [2.07-5.71]) compared with controls (n=17, age 61 +/- 8 years, remnant cholesterol 0.29 [0.27-0.40]; P