Antigen capture in chicken spleen during the primary immune response and relationship to phagocytic activity.
Antigen capture in chicken spleen during the primary immune response and relationship to phagocytic activity.
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初次免疫反应期间鸡脾中抗原的捕获及其与吞噬活性的关系。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
Zsuzsanna Urban
中科院分区：
文献类型：
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作者：
Z. Nagy;E. Horváth;Zsuzsanna Urban
抗原在哺乳动物淋巴结和脾脏中的定位已被广泛研究1。然而，关于抗原在家禽中的分布的信息很少。鸡没有淋巴结，因此脾脏是其主要的外周淋巴器官。因此，尽管弥漫性器官相关淋巴组织5的免疫反应性不可忽视，但在抗体产生中的主要作用归因于脾脏2 -4。白色等人6、7的免疫荧光和放射自显影研究集中于次级脾滤泡和动脉周围网状细胞的抗原捕获能力。本实验室目前的实验，使用131 I标记或125 I标记的牛血清白蛋白（BSA），已显示出显着的保留抗原在鸡脾脏，主要是由红髓巨噬细胞和网状细胞形成的Schweigger-Seidel毛细血管鞘。巨噬细胞摄取抗原的能力源于其吞噬活性，而Schweigger-Seidel鞘的抗原捕获可能与吞噬无关。
THE localization of antigen in the lymph nodes and spleens of mammals has been extensively studied1. Little information is available, however, on the distribution of antigen in the fowl. The chicken has no lymph nodes and so the spleen is its main peripheral lymphoid organ. The principal role in antibody production is therefore attributed to the spleen2–4, although the immune responsiveness of diffuse organ-associated lymphoid tissue5 cannot be neglected. The immunofluorescence and autoradiographic studies of White et al.6,7 focused on the antigen trapping capacity of secondary splenic follicles and periarteriolar reticular cells. Present experiments in this laboratory, using 131I-labelled or 125I-labelled bovine serum albumin (BSA), have shown a marked retention of antigen in the chicken spleen, chiefly by red pulp macrophages and reticulum cells forming the Schweigger-Seidel capillary sheaths. The capacity of macrophages for antigen uptake stems from their phagocytic activity, whereas antigen capture by Schweigger-Seidel sheaths is probably unrelated to phagocytosis.