Neonatal herpes simplex virus infection.
Neonatal herpes simplex virus infection.
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新生儿单纯疱疹病毒感染。
DOI：
10.1097/grf.0b013e31827146a7
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发表时间：
2012
影响因子：
1.5
通讯作者：
Maryak,SamanthaA
中科院分区：
文献类型：
--
作者：
Cherpes,ThomasL;Matthews,DeanB;Maryak,SamanthaA
在美国，新生儿疱疹大约每3000例活产中就有1例，是围产期单纯疱疹病毒（HSV）感染最严重的表现。虽然阿昔洛韦治疗降低了与围产期HSV传播相关的婴儿死亡率，但永久性神经功能障碍的发生并不罕见。当母亲生殖道HSV感染接近分娩时，母婴HSV传播最有效，这意味着新生儿疱疹预防策略需要专注于降低妊娠期间母亲感染的发生率，并更准确地识别最有可能从预防性抗病毒治疗中受益的婴儿。
Neonatal herpes, seen roughly in 1 of 3000 live births in the United States, is the most serious manifestation of herpes simplex virus (HSV) infection in the perinatal period. Although acyclovir therapy decreases infant mortality associated with perinatal HSV transmission, development of permanent neurological disabilities is not uncommon. Mother-to-neonate HSV transmission is most efficient when maternal genital tract HSV infection is acquired proximate to the time of delivery, signifying that neonatal herpes prevention strategies need to focus on decreasing the incidence of maternal infection during pregnancy and more precisely identifying infants most likely to benefit from prophylactic antiviral therapy.