Introduction: History of SH2 Domains and Their Applications.
Introduction: History of SH2 Domains and Their Applications.
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简介：SH2 域的历史及其应用。
DOI：
10.1007/978-1-4939-6762-9_1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Machida,Kazuya
中科院分区：
文献类型：
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作者：
Liu,BernardA;Machida,Kazuya
Src 同源 2 (SH2) 结构域是典型的蛋白质相互作用模块，位于磷酸酪氨酸信号传导的核心。自偶然发现以来，技术取得了巨大进步，可用于研究 SH2 结构域和磷酸酪氨酸信号传导的技术也不断涌现。在本章中，我们概述了 SH2 域的历史，描述了在此过程中开发的许多工具和技术，并讨论了 SH2 域研究的未来方向。我们在以下背景下强调了本卷中每一章的要点：结构生物学和磷酸酪氨酸结合；表征 SH2 特异性并生成预测模型；系统生物学和蛋白质组学； SH2 结构域在信号转导中的作用；和 SH2 领域的疾病、诊断和治疗。许多单独的章节提供了深入的方法，使科学家能够探究 SH2 结构域的功能和作用。
The Src Homology 2 (SH2) domain is the prototypical protein interaction module that lies at the heart of phosphotyrosine signaling. Since its serendipitous discovery, there has been a tremendous advancement in technologies and an array of techniques available for studying SH2 domains and phosphotyrosine signaling. In this chapter, we provide a glimpse of the history of SH2 domains and describe many of the tools and techniques that have been developed along the way and discuss future directions for SH2 domain studies. We highlight the gist of each chapter in this volume in the context of: the structural biology and phosphotyrosine binding; characterizing SH2 specificity and generating prediction models; systems biology and proteomics; SH2 domains in signal transduction; and SH2 domains in disease, diagnostics, and therapeutics. Many of the individual chapters provide an in-depth approach that will allow scientists to interrogate the function and role of SH2 domains.