Aberrant auditory processing in schizophrenia and in subjects at ultra-high-risk for psychosis.
Aberrant auditory processing in schizophrenia and in subjects at ultra-high-risk for psychosis.
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DOI：
10.1093/schbul/sbr138
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发表时间：
2012-11
影响因子：
6.6
通讯作者：
K. Shin;J. Kim;Sung Nyun Kim;Y. Koh;J. Jang;S. An;B. O’Donnell;C. Chung;J. Kwon
中科院分区：
文献类型：
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作者：
K. Shin;J. Kim;Sung Nyun Kim;Y. Koh;J. Jang;S. An;B. O’Donnell;C. Chung;J. Kwon
在脑电图和脑磁图（MEG）记录中观察到的N1和失配负波（MMN）反应反映了感觉加工、感觉记忆和适应，通常在精神分裂症患者中异常。然而，它们对超高风险（UHR）状态的差异敏感性存在争议。本研究评价了16例UHR受试者、15例精神分裂症患者和18例健康对照者（HC）在被动听觉oddball任务中MEG N1m、N1m适应和MMN磁对应物（MMNm）的敏感性。使用标准刺激序列中第一个和最后一个标准音之间的N1m偶极矩差异评估N1m适应。N1m适应发生在HC，而无论是UHR还是精神分裂症组显示适应标准音重复演示。UHR组的值介于HC和精神分裂症患者之间。此外，与HC相比，UHR组和患者组的MMNm偶极矩均降低，而UHR组和精神分裂症组之间没有差异。这些研究结果表明，无论是N1m适应和MMNm改变UHR科目和精神分裂症患者，尽管未受影响的N1m偶极矩的第一个标准音。此外，UHR和精神分裂症组未能显示适应的N1m重复标准音。这种适应失败在患者中比UHR受试者更严重，这表明听觉适应可能对疾病的进展敏感，并且是UHR精神病的早期生物标志物。另一方面，听觉感觉记忆的缺陷在两组中可能类似地受损。
The N1 and the mismatch negativity (MMN) responses observed in electroencephalographic and magnetoencephalographic (MEG) recordings reflect sensory processing, sensory memory, and adaptation and are usually abnormal in patients with schizophrenia. However, their differential sensitivity to ultra-high-risk (UHR) status is controversial. The current study evaluated the sensitivity of MEG N1m, N1m adaptation, and magnetic counterpart of MMN (MMNm) in 16 UHR subjects, 15 schizophrenia patients, and 18 healthy controls (HCs) during a passive auditory oddball task. N1m adaptation was assessed using the difference in N1m dipole moment between the first and last standard tones in a standard stimulus sequence. N1m adaptation occurred in HCs, whereas neither the UHR nor the schizophrenia groups showed adaptation to the standard tone on repeated presentations. The UHR group had values between those for HCs and schizophrenia patients. Additionally, MMNm dipole moment was reduced in both the UHR and patient groups compared with HCs, whereas the UHR and schizophrenia groups did not differ from each other. These findings indicated that both N1m adaptation and MMNm were altered in UHR subjects and in schizophrenia patients, despite unaffected N1m dipole moment to the first standard tones. Moreover, both UHR and schizophrenia groups failed to show adaptation of the N1m to repeated standard tones. This failure in adaptation was more severe in patients than UHR subjects, suggesting that auditory adaptation may be sensitive to the progression of the illness and be an early biomarker of UHR for psychosis. Deficits in auditory sensory memory, on the other hand, may be similarly impaired in both groups.