Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats
Intermittent hypoxia causes mandibular growth retardation and macroglossia in growing rats
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DOI：
10.1016/j.ajodo.2016.02.033
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发表时间：
2017-02-01
影响因子：
3
通讯作者：
Ono, Takashi
中科院分区：
文献类型：
--
作者：
Hosomichi, Jun;Kuma, Yo-ichiro;Ono, Takashi
引言：在这项研究中，我们的目的是研究间歇性缺氧（IH）在生长期大鼠牙面形态学变化中的作用。研究方法：将7周龄的雄性大鼠以每小时20个循环（4%氧气的最低点到21%氧气的峰值）暴露于IH，每天8小时，持续6周.对照大鼠暴露于常氧（N）。通过头影测量X线片上的线性测量比较两组之间的颌面生长。为了检查牙弓形态，拍摄了颌骨的研究模型和微型计算机断层扫描图像。此外，还测量了舌头的大小。结果如下：IH组的下颌角和下颌支小于N组，而体重在两组之间没有差异。齿列形态测量分析显示，一个显着更广泛的下颌牙列和狭窄的上颌牙列在IH比N组。IH组的舌到下颌骨的相对宽度（+14.2%）和长度（舌尖到锯齿状乳头，13.5%）显著大于N组。结论：间歇性低氧可导致生长期大鼠牙面形态学差异。
Introduction: In this study, we aimed to examine the role of intermittent hypoxia ( IH) in dentofacial morphologic changes in growing rats. Methods: Seven- week- old male rats were exposed to IH at 20 cycles per hour ( nadir of 4% oxygen to peak of 21% oxygen) for 8 hours per day for 6 weeks. Control rats were exposed to normoxia ( N). Maxillofacial growth was compared between the 2 groups by linear measurements on cephalometric radiographs. To examine the dental arch morphology, study models and microcomputed tomography images of the jaws were taken. Additionally, tongue size was measured. Results: The gonial angle and the ramus of the mandible were smaller in the IH group than in the N group, whereas the body weights were not different between the 2 groups. Morphometric analysis of the dentition showed a significantly wider mandibular dentition and narrower maxillary dentition in the IH than in the N group. The relative width ( +14.2 %) and length ( tongue apex to vallate papillae, 13.5 %) of the tongue to the mandible were significantly greater in the IH group than in the N group. Conclusions: IH induced dentofacial morphologic discrepancies in growing rats.