Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.
Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.
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Aiolos 通过沉默癌细胞中的 p66(Shc) 转录来促进锚固独立
DOI：
10.1016/j.ccr.2014.03.020
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发表时间：
2014-05-12
期刊：
影响因子：
50.3
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Li X;Xu Z;Du W;Zhang Z;Wei Y;Wang H;Zhu Z;Qin L;Wang L;Niu Q;Zhao X;Girard L;Gong Y;Ma Z;Sun B;Yao Z;Minna JD;Terada LS;Liu Z
组织细胞对它们的物理环境的锚定是存活的必要条件，其在成熟的造血细胞和转化的上皮细胞中丧失。在这里，我们发现淋巴细胞谱系限制性转录因子Aiolos经常在肺癌中表达，并预测患者生存率显着降低。Aiolos降低了大量粘附相关基因的表达，破坏了细胞-细胞和细胞-基质的相互作用。Aiolos还重构SHC 1基因内的染色质结构，导致锚定报告基因p66 Shc的同种型特异性沉默，并在体外和体内阻断失巢凋亡。在肺癌组织和单个细胞中，p66 Shc的表达与Aiolos的表达呈负相关。总之，这些发现表明Aiolos在转移性上皮癌中作为淋巴细胞拟态的表观遗传驱动因素发挥作用。
Anchorage of tissue cells to their physical environment is an obligate requirement for survival which is lost in mature hematopoietic and in transformed epithelial cells. Here we find that a lymphocyte lineage-restricted transcription factor, Aiolos, is frequently expressed in lung cancers and predicts markedly reduced patient survival. Aiolos decreases expression of a large set of adhesion-related genes, disrupting cell-cell and cell-matrix interactions. Aiolos also reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66Shc and blocking anoikis in vitro and in vivo. In lung cancer tissues and single cells, p66Shc expression inversely correlates with that of Aiolos. Together, these findings suggest that Aiolos functions as an epigenetic driver of lymphocyte mimicry in metastatic epithelial cancers.
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影响因子：
20.3
作者：
Billot, Katy;Soeur, Jeremie;Rebollo, Angelita
通讯作者：
Rebollo, Angelita
影响因子：
30.8
作者：
Holmfeldt, Linda;Wei, Lei;Diaz-Flores, Ernesto;Walsh, Michael;Zhang, Jinghui;Ding, Li;Payne-Turner, Debbie;Churchman, Michelle;Andersson, Anna;Chen, Shann-Ching;McCastlain, Kelly;Becksfort, Jared;Ma, Jing;Wu, Gang;Patel, Samir N.;Heatley, Susan L.;Phillips, Letha A.;Song, Guangchun;Easton, John;Parker, Matthew;Chen, Xiang;Rusch, Michael;Boggs, Kristy;Vadodaria, Bhavin;Hedlund, Erin;Drenberg, Christina;Baker, Sharyn;Pei, Deqing;Cheng, Cheng;Huether, Robert;Lu, Charles;Fulton, Robert S.;Fulton, Lucinda L.;Tabib, Yashodhan;Dooling, David J.;Ochoa, Kerri;Minden, Mark;Lewis, Ian D.;To, L. Bik;Marlton, Paula;Roberts, Andrew W.;Raca, Gordana;Stock, Wendy;Neale, Geoffrey;Drexler, Hans G.;Dickins, Ross A.;Ellison, David W.;Shurtleff, Sheila A.;Pui, Ching-Hon;Ribeiro, Raul C.;Devidas, Meenakshi;Carroll, Andrew J.;Heerema, Nyla A.;Wood, Brent;Borowitz, Michael J.;Gastier-Foster, Julie M.;Raimondi, Susana C.;Mardis, Elaine R.;Wilson, Richard K.;Downing, James R.;Hunger, Stephen P.;Loh, Mignon L.;Mullighan, Charles G.
通讯作者：
Mullighan, Charles G.
影响因子：
8
作者：
Ma, Z.;Liu, Z.;Wu, R-F;Terada, L. S.
通讯作者：
Terada, L. S.
影响因子：
64.5
作者：
Giorgio, M;Migliaccio, E;Pelicci, PG
通讯作者：
Pelicci, PG
影响因子：
1.9
作者：
Fischer, Barbara;Arcaro, Alexandre
通讯作者：
Arcaro, Alexandre