MicroRNAs and lung cancers: from pathogenesis to clinical implications.
MicroRNAs and lung cancers: from pathogenesis to clinical implications.
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DOI：
10.1007/s11684-012-0188-4
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发表时间：
2012-06
影响因子：
8.1
通讯作者：
Mu, David
中科院分区：
文献类型：
--
作者：
Qi, Ji;Mu, David
肺癌是美国以及全球癌症相关死亡的首要原因。为了改善临床治疗，有必要更好地了解这种疾病。在此我们总结了基于小RNA的转录后基因调节因子，即微小RNA（microRNAs）在肺癌发病机制中的作用。我们讨论了具有致癌作用以及肿瘤抑制作用的微小RNA。我们还提及了微小RNA作为诊断、预后标志物的价值，以及基于微小RNA的肺癌新型疗法这一有前景的领域。
Lung cancer is the leading cause of cancer-related deaths in the US and worldwide. Better understanding of the disease is warranted for improvement in clinical management. Here we summarize the functions of small-RNA-based, posttranscriptional gene regulators, i.e. microRNAs, in the pathogenesis of lung cancers. We discuss the microRNAs that play oncogenic as well as tumor suppressive roles. We also touch on the value of microRNAs as markers for diagnosis, prognosis and the promising field of microRNA-based novel therapies for lung cancers.