Testosterone levels among men with spinal cord injury - Relationship between time since injury and laboratory values
Testosterone levels among men with spinal cord injury - Relationship between time since injury and laboratory values
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DOI：
10.1097/phm.0b013e3181837f4f
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发表时间：
2008-09-01
影响因子：
3
通讯作者：
Acuff, Michael E.
中科院分区：
文献类型：
--
作者：
Clark, Mary J.;Schopp, Laura H.;Acuff, Michael E.
目的：本研究的目的是确定低睾丸激素的患病率与脊髓损伤的男性样本之间的关系，并检查睾丸激素，受伤后的时间，并选择实验室values.Design：参与者是102名男性脊髓损伤参与住院或门诊康复。数据包括总血清睾酮水平，人口统计学和损伤信息，和实验室values.Results：60%的男性脊髓损伤有低睾酮水平。整个样本的中位睾酮水平为220 ng/dl（正常参考范围= 241 - 827 ng/dl）。在单因素分析中，低睾酮与损伤后较短的时间、较低的血红蛋白和较高的催乳素显著相关（P <0.05）。结论：结果表明，男性脊髓损伤患者存在低血清睾酮的风险。睾酮水平也与受伤后的时间、血红蛋白和催乳素水平有关。这些发现表明需要在临床实践中进行改变。需要指导何时以及多久进行睾酮监测。未来的研究应该解决低睾酮的病理生理学和睾酮治疗的结果。
Objectives: The objectives of the present study were to determine the prevalence of low testosterone among a sample of men with spinal cord injury and to examine the relationship among testosterone, time since injury, and select laboratory values.Design: Participants were 102 men with spinal cord injury participating in inpatient or outpatient rehabilitation. Data included total serum testosterone level, demographic and injury information, and laboratory values.Results: Sixty percent of men with spinal cord injury had low testosterone levels. The median testosterone level for the entire sample was 220 ng/dl (normal reference range = 241-827 ng/dl). Low testosterone was significantly associated with less time since injury, lower hemoglobin, and higher prolactin in the univariate analyses at P < 0.05.Conclusions: The results indicate that men with spinal cord injury are at risk for low serum testosterone. Testosterone levels were also related to time since injury and hemoglobin and prolactin levels. These findings suggest the need for changes to occur in clinical practice. Guidelines are needed for when and how often testosterone monitoring should be conducted. Future research should address the pathophysiology of low testosterone and the outcomes of testosterone treatment.