Differential roles of the dorsal hippocampal regions in the acquisition of spatial and temporal aspects of episodic-like memory
Differential roles of the dorsal hippocampal regions in the acquisition of spatial and temporal aspects of episodic-like memory
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DOI：
10.1016/j.bbr.2012.04.022
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发表时间：
2012-06-15
影响因子：
2.7
通讯作者：
Silva, Regina Helena
中科院分区：
文献类型：
--
作者：
Barbosa, Flavio Freitas;de Oliveira Pontes, Isabella Maria;Silva, Regina Helena
情景记忆是指对事件发生的内容、地点和时间的回忆。计算模型表明，齿状回 (DG) 和 CA3 海马亚区参与模式分离和事件的快速获取，而 CA1 参与时间背景的形成。大多数为检验这一假设而进行的研究未能同时解决情景记忆的各个方面。最近，一项新的物体识别任务在大鼠身上得到了验证。在第一个样本试验中，老鼠暴露于一个物体的四个副本。在第二个样本中，老鼠暴露于不同物体的四个副本。在测试中，提供了每个先前对象的两个副本。样本试验一中使用的物体的一份副本位于不同的地方，预计它是探索最多的。我们的目标是评估背侧 DG/CA3 和 CA1 亚区的药理学失活是否会不同程度地损害任务的获得。 DG/CA3 亚区的失活损害了空间辨别力，而时间辨别力得以保留。在 CA1 中接受蝇蕈醇治疗的老鼠对所有物体的探索效果都一样好，无论地点或呈现时间如何。我们的结果与计算模型一致，计算模型假设 DG/CA3 在快速编码和空间模式分离中发挥作用，而 CA1 在事件时间背景的形成以及检测空间新颖性中发挥作用。 (C) 2012 Elsevier B.V. 保留所有权利。
Episodic memory refers to the recollection of what, where and when an event occurred. Computational models suggest that the dentate gyrus (DG) and the CA3 hippocampal subregions are involved in pattern separation and the rapid acquisition of episodes, while CA1 is involved in the formation of a temporal context. Most of the studies performed to test this hypothesis failed to simultaneously address the aspects of episodic memory. Recently, a new task of object recognition was validated in rats. In the first sample trial, the rat is exposed to four copies of an object. In second sample, the rat is exposed to four copies of a different object. In the test trial, two copies of each of the previous objects are presented. One copy of the object used in sample trial one is located in a different place, and it is expected to be the most explored. Our goal was to evaluate whether the pharmacological inactivation of the dorsal DG/CA3 and CA1 subregions could differentially impair the acquisition of the task. Inactivation of the DG/CA3 subregions impaired the spatial discrimination, while the temporal discrimination was preserved. Rats treated with muscimol in CA1 explored all the objects equally well, irrespective of place or presentation time. Our results are consistent with computational models that postulate a role for DG/CA3 in rapid encoding and in spatial pattern separation, and a role for CA1 in the in the formation of the temporal context of events and as well as in detecting spatial novelty. (C) 2012 Elsevier B.V. All rights reserved.