Construction of a Well-Defined Multifunctional Dendrimer for Theranostics
Construction of a Well-Defined Multifunctional Dendrimer for Theranostics
复制标题
DOI：
10.1021/ol103019z
复制
发表时间：
2011-03-04
期刊：
影响因子：
5.2
通讯作者：
Weck, Marcus
中科院分区：
文献类型：
--
作者：
Ornelas, Catia;Pennell, Ryan;Weck, Marcus
设计了一种基于树枝状大分子的抗辐射积木。该多功能树状大分子是以聚酰胺为基础的，含有9个叠氮末端、9个胺末端和54个末端酸基。将该多功能树状大分子与近红外(NIR)菁染料进行正交官能化，得到了在近红外区域显示荧光且对T98G人类细胞无毒性的最终树状大分子。这里描述的合成策略可能在制造下一代抗辐射材料方面很有前途。
A dendrimer-based building block for theranostics was designed. The multifunctional dendrimer is polyamide-based and contains nine azide termini, nine amine termini, and fifty-four terminal acid groups. Orthogonal functionalization of the multifunctional dendrimer with a near-infrared (NIR) cyanine dye afforded the final dendrimer that shows fluorescence in the NIR region and no toxicity toward T98G human cells. The synthetic strategy described here might be promising for fabricating the next generation of materials for theranostics.