Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma
Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma
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DOI：
10.1046/j.1464-410x.2001.02231.x
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发表时间：
2001-07-01
影响因子：
4.5
通讯作者：
Gögüs, O
中科院分区：
文献类型：
--
作者：
Baltaci, S;Orhan, D;Gögüs, O
目的探讨诱导型一氧化氮合酶（inducible nitric oxide synthase，iNOS）在良性前列腺增生（benign prostate hyperplasia，BPH）、低度和高度前列腺上皮内瘤变（prostate intraepithelial neoplasia，PIN）及前列腺癌组织中的表达及其在前列腺肿瘤发生中的作用。结果iNOS在所有患者的前列腺组织中均呈阳性表达，在前列腺上皮的基底细胞和分泌细胞中均有表达。高级别PIN和前列腺癌组织中iNOS的表达较低级别PIN和前列腺增生组织中强。结论iNOS产生的一氧化氮可能参与了前列腺肿瘤的发生，iNOS在前列腺肿瘤发生中的确切作用有待于进一步的免疫组化和分子生物学研究。前列腺癌的发病机制
Objective To elucidate the incidence of inducible nitric oxide synthase (iNOS) expression in benign prostatic hyperplasia (BPH), low- and high-grade prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma lesions, and to explore the role of iNOS in prostate tumorigenesis.Materials and methods Immunoreactivity for iNOS was examined in 20 samples each of BPH, high-grade PIN, low-grade PIN and prostatic carcinoma.Results Positive iNOS immunostaining was detected in all samples from all patients; iNOS was detected in both basal epithelial cells and secretory cells of the glandular epithelium. High-grade PIN and prostatic carcinoma samples had more intense iNOS immunostaining than low-grade PIN and BPH samples, In all samples, smooth muscle cells showed weal; or moderate iNOS immunoreactivity and endothelial cells showed moderate immunostaining.Conclusions Nitric oxide generated by iNOS may be involved in prostate tumorigenesis and further studies with immunohistochemical and molecular biology are needed to determine the exact role of iNOS in the pathogenesis oif prostatic carcinoma.