Lignans from the stems of Sambucus williamsii and their effects on osteoblastic UMR106 cells
Lignans from the stems of Sambucus williamsii and their effects on osteoblastic UMR106 cells
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DOI：
10.1080/10286020500530433
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Yao, Xin-Sheng
中科院分区：
文献类型：
--
作者：
Yang, Xu-Juan;Wong, Man-Sau;Yao, Xin-Sheng
三种新木脂素，接骨木醇 A (8) ((+)-赤式-1-(4-羟基-3-甲氧基苯基)-2-[4-(4-羟基-3-甲氧基肉桂酰氧基丙基)-2-羟基苯氧基]-1, 3-丙二醇)、接骨木醇 B (9) ((+)-苏-1-(4-羟基-3-甲氧基苯基)-2-[4-(4-羟基-3-甲氧基-肉桂酰氧基丙基)-2-羟基苯氧基]-1, 3-丙二醇) 和 Buddlenol G (10) (2-{4-[2, 3-二氢-3-羟甲基-7-羟基-5-(4-羟基-3-甲氧基肉桂酰氧基丙基)-2-苯并呋喃基]-2,6-二甲氧基苯氧基}-1-(4-羟基-3-甲氧基苯基)-1, 3-丙二醇)，以及七种已知的，包括(-)-丁香树脂醇(1)、(-)-松脂醇(2)、1、 2-双(4-羟基-3-甲氧基苯基)-1, 3-丙二醇(3), (-)-赤式-1-(4-羟基-3-甲氧基苯基)-2-[4-(3-羟基丙基)-2-甲氧基苯氧基]-1, 3-丙二醇(4),采用色谱法从接骨木茎的 60% 乙醇提取物中分离得到 (-)-苏型-1-(4-羟基-3-甲氧基苯基)-2-[4-(3-羟基丙基)-2-甲氧基苯氧基]-1、3-丙二醇 (5)、(-)-落叶松树脂醇 (6) 和 (-)-二氢脱氢二松树醇 (7)。它们的结构是通过光谱分析确定的。确定了分离的化合物对成骨细胞样 UMR106 细胞增殖和 ALP 活性的影响。化合物2、7和10对UMR106细胞增殖和ALP活性均显示出刺激作用。化合物1、3、6和8刺激UMR106细胞增殖，而化合物4和5诱导UMR106细胞中的ALP活性。
Three new lignans, sambucunol A (8) ((+)-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-hydroxyphenoxy]-1, 3-propanediol), sambucunol B (9) ((+)-threo-1-(4-hydroxyl-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxy-cinnamoyloxy propanyl)-2-hydroxyphenoxy]-1, 3-propanediol) and buddlenol G (10) (2-{4-[2, 3-dihydro-3-hydroxymethyl-7-hydroxy-5-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-benzofuranyl]-2,6-dimethoxyphenoxy}-1-(4- hydroxy-3-methoxyphenyl) -1, 3-propanediol), along with seven known ones, including (-)-syringaresinol (1), (-)-pinoresinol (2), 1, 2-bis(4-hydroxy-3-methoxy phenyl)-1, 3-propanediol (3), (-)-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy propanyl)-2-methoxyphenoxy]-1, 3-propanediol (4), (-)-threo-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropanyl)-2-methoxy phenoxy]-1, 3-propanediol (5), (-)-lariciresinol (6) and (-)-dihydrodehydrodiconiferyl alcohol (7), were isolated from the 60% ethanol extract of stems of Sambucus williamsii Hance by chromatographic methods. Their structures were established by spectral analysis. The effects of isolated compounds on the osteoblast-like UMR106 cell proliferation and ALP activities were determined. Compounds 2, 7 and 10 showed stimulating effects both on UMR106 cell proliferation and ALP activity. Compounds 1, 3, 6 and 8 stimulated UMR106 cell proliferation, while compounds 4 and 5 induced ALP activity in UMR106 cell.