A low-dimensional model for the red blood cell.
A low-dimensional model for the red blood cell.
复制标题
红细胞的低维模型。
DOI：
10.1039/c0sm00183j
复制
发表时间：
2010-09-21
期刊：
影响因子：
3.4
通讯作者：
Karniadakis GE
中科院分区：
文献类型：
--
作者：
Pan W;Caswell B;Karniadakis GE
红细胞 (RBC) 因其主要的数量密度、特殊的机械性能和动力学特性而成为血液流变特性的重要决定因素。在这里，我们开发了一种基于耗散粒子动力学（DPD）的新低维 RBC 模型。该模型被构造为由 10 个胶体颗粒组成的闭合环面环，通过蠕虫链弹簧与抗弯力相结合。每个胶体颗粒由具有排斥核的单个 DPD 颗粒表示。该模型能够捕捉红细胞的基本机械特性，并允许经济地探索红细胞悬浮液的流变学。具体来说，我们发现健康细胞和疟疾感染细胞的线性和非线性弹性变形与光镊实验中获得的结果相匹配。通过模拟血管中血流的一些关键特征，即无细胞层（CFL）、Fahraeus 效应和 Fahraeus-Lindqvist 效应，我们验证了新模型捕获了真实血液的基本剪切流特性，但尺寸与细胞直径相当的毛细血管除外。最后，我们研究了流动中的几何收缩对增强下游 CFL 的影响。我们的结果与最近的实验一致。
The red blood cell (RBC) is an important determinant of the rheological properties of blood because of its predominant number density, special mechanical properties and dynamics. Here, we develop a new low-dimensional RBC model based on dissipative particle dynamics (DPD). The model is constructed as a closed-torus-like ring of 10 colloidal particles connected by wormlike chain springs combined with bending resistance. Each colloidal particle is represented by a single DPD particle with a repulsive core. The model is able to capture the essential mechanical properties of RBCs, and allows for economical exploration of the rheology of RBC suspensions. Specifically, we find that the linear and non-linear elastic deformations of healthy and malaria-infected cells match those obtained in optical tweezers experiments. Through simulations of some key features of blood flow in vessels, i.e., the cell-free layer (CFL), the Fahraeus effect and the Fahraeus-Lindqvist effect, we verify that the new model captures the essential shear flow properties of real blood, except for capillaries of sizes comparable to the cell diameter. Finally, we investigate the influence of a geometrical constriction in the flow on the enhancement of the downstream CFL. Our results are in agreement with recent experiments.