Fine-needle aspiration of synovial sarcoma:: Criteria for diagnosis:: Retrospective reexamination of 37 cases, including ancillary diagnostics.: A Scandinavian sarcoma group study
Fine-needle aspiration of synovial sarcoma:: Criteria for diagnosis:: Retrospective reexamination of 37 cases, including ancillary diagnostics.: A Scandinavian sarcoma group study
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DOI：
10.1002/dc.10265
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发表时间：
2003-05-01
影响因子：
1.3
通讯作者：
Skytting, B
中科院分区：
文献类型：
--
作者：
Åkerman, M;Ryd, W;Skytting, B
细针穿刺滑膜肉瘤的细胞学标准是通过对37例原发肿瘤的回顾性检查确定的。无论亚型如何，只要产量丰富，在低功率下都发现了典型的模式。典型的模式是分散的细胞与条纹状细胞核和细胞紧密的肿瘤组织碎片与不规则的边界的存在的混合物。通常在碎片中存在分支血管网络，模仿真正的血管肿瘤。除低分化滑膜肉瘤外，肿瘤细胞大小为小至中等，核呈圆形、卵圆形或梭形，核仁不明显。在双相变异中，存在小的腺样或腺泡样结构，尽管并非在所有病例中。然而，在低分化型中，细胞多形性以具有不规则核的细胞和横纹肌样细胞的存在为标志，对应于多形性变体。尤文肉瘤样和低分化滑膜肉瘤的非典型梭形细胞变体在材料中未被诊断。当产量丰富时，肉瘤的明确诊断是可能的。然而，辅助诊断对于正确诊断是必要的，以避免重要的陷阱，例如具有温和肿瘤细胞和富含血管的肿瘤碎片的其他肉瘤，特别是孤立性纤维瘤和真正的血管外皮细胞瘤。电子显微镜和/或分子遗传学分析是比免疫细胞化学更好的诊断方法。(C)2003 Wiley-Liss，Inc.
The cytologic criteria of synovial sarcoma in fine-needle aspirates were defined by a retrospective examination of 37 primary tumors. Irrespective of subtype, a typical pattern at low power was found, provided the yield was rich. The typical pattern was a mixture of dispersed cells with the presence of striped nuclei and cell-tight tumor tissue fragments with irregular borders. Often a branching network of vessels was present in the fragments, imitating a true vascular tumor. Except in poorly differentiated synovial sarcomas, the tumor cells were, small to medium in size, with rounded, ovoid, or fusiform bland nuclei with inconspicuous nucleoli. In the biphasic variant, small glandular- or acinar-like structures were present, although not in all cases. In the poorly differentiated type, however, the cellular pleomorphism was marked with the presence of cells with irregular nuclei and rhabdomyoblast-like cells, corresponding to the pleomorphic variant. The Ewing's sarcoma-like and the atypical spindle cell variants of poorly differentiated synovial sarcoma were not diagnosed in the material. An unequivocal diagnosis of sarcoma is possible when the yield is rich. However, ancillary diagnostics are necessary for a correct diagnosis, to avoid important pitfalls, such as other sarcomas with bland tumor cells and vessel-rich tumor fragments, in particular, solitary fibrous tumor and true hemangiopericytoma. Electron microscopic and/or molecular genetic analyses were better diagnostic adjuncts than immunocytochemistry. (C) 2003 Wiley-Liss, Inc.