The Child Behavior Checklist-Pediatric Bipolar Disorder Profile Predicts a Subsequent Diagnosis of Bipolar Disorder and Associated Impairments in ADHD Youth Growing Up: A Longitudinal Analysis
The Child Behavior Checklist-Pediatric Bipolar Disorder Profile Predicts a Subsequent Diagnosis of Bipolar Disorder and Associated Impairments in ADHD Youth Growing Up: A Longitudinal Analysis
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DOI：
10.4088/jcp.08m04821
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发表时间：
2009-05-01
影响因子：
5.3
通讯作者：
Wozniak, Janet
中科院分区：
文献类型：
--
作者：
Biederman, Joseph;Petty, Carter R.;Wozniak, Janet
目的：研究儿童行为检查表-儿童双相情感障碍（CBCL-PBD）档案的预测效用，以帮助识别有双相情感障碍风险的儿童。方法：从2个相同设计的DSM-III-R型注意缺陷/多动障碍（ADHD）患者（6-18岁的男性和女性）纵向病例对照家庭研究中确定受试者。根据基线评估的数据，没有终身诊断为双相情感障碍的ADHD受试者按存在（CBCL-PBD阳性）进行分层。N = 28)或CBCL-PBD评分缺失（CBCL-PBD阴性，N = 176） >= 210（注意、攻击和焦虑/抑郁分量表总数）。在随访中，通过结构化的精神病学访谈对受试者进行全面评估。数据收集时间为1988年4月至2003年2月。结果：在平均7.4年的随访期间，CBCL-PBD评分阳性预示着随后的双相情感障碍、重度抑郁症和品行障碍的诊断，以及心理社会功能受损和精神病住院的高风险。结论：这项工作表明，基于注意问题、攻击行为和焦虑/抑郁亚量表的CBCL-PBD评分阳性可以预测随后的儿童双相情感障碍和相关的综合征-一致性障碍。如果在其他研究中得到证实，CBCL-PBD评分有可能帮助识别患双相情感障碍的高风险儿童。临床精神病学杂志2009:70(5):732-740 (C)版权所有2009年医师研究生出版社，Inc。
Objective: To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder.Method: Subjects were ascertained from 2 identically designed longitudinal case-control family studies of subjects (males and females aged 6-18 years) with DSM-III-R attention-deficit/hyperactivity disorder (ADHD). Based on data from the baseline assessment, ADHD subjects without a lifetime diagnosis of bipolar disorder were stratified by the presence (CBCL-PBD positive. N = 28) or absence (CBCL-PBD negative, N = 176) of a CBCL-PBD score >= 210 (total of attention, aggression, and anxious/depressed subscales). Subjects were comprehensively assessed at follow-up with structured psychiatric interviews. Data were collected from April 1988 to February 2003.Results: Over a mean follow-up period of 7.4 years, a positive CBCL-PBD score predicted subsequent diagnoses of bipolar disorder, major depressive disorder, and conduct disorder, as well as impaired psychosocial functioning and higher risk for psychiatric hospitalization.Conclusions: This work suggests that a positive CBCL-PBD score based on elevations on the attention problems, aggressive behavior, and anxious/depressed subscales predicts subsequent pediatric bipolar disorder and associated syndrome-congruent impairments. if confirmed in other studies, the CBCL-PBD score has the potential to help identify children at high risk to develop bipolar disorder. J Clin Psychiatry 2009:70(5):732-740 (C) Copyright 2009 Physicians Postgraduate Press, Inc.