Body size and risk of colon and rectal cancer in the European prospective investigation into cancer and nutrition (EPIC)
Body size and risk of colon and rectal cancer in the European prospective investigation into cancer and nutrition (EPIC)
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DOI：
10.1093/jnci/djj246
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发表时间：
2006-07-05
期刊：
影响因子：
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通讯作者：
Riboli, Elio
中科院分区：
文献类型：
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作者：
Pischon, Tobias;Lahmann, Petra H.;Riboli, Elio
背景资料：体重和体重指数（BMI）与男性结肠癌风险呈正相关，而女性中存在微弱或无相关性。这种差异可能与性别之间脂肪分布的差异或女性激素替代疗法（HRT）的使用有关。研究方法：我们使用多变量校正的考克斯比例风险模型，在来自欧洲癌症和营养前瞻性调查的9个国家的368277名基线时无癌症的男性和女性中，研究人体测量指标与结肠癌和直肠癌风险之间的关系。所有统计检验均为双侧检验。结果：在6.1年的随访中，我们分别确定了984例和586例结肠癌和直肠癌患者。在男性中，体重和BMI与结肠癌风险在统计学上显著相关（BMI的最高五分位数与最低五分位数，相对风险[RR] = 1.55，95%置信区间[CI] = 1.12至2.15; P趋势= 0.006），但在女性中不相关。相比之下，对最高和最低五分位数的比较表明，包括腰围在内的几项人体测量指标，（男性，RR = 1.39，95%CI = 1.01 - 1.93; P趋势= 0.001;女性，RR = 1.48，95%CI = 1.08 - 2.03; P趋势= 0.008），腰臀比（WHR;男性，RR = 1.51，95% CI = 1.06至2.15; P趋势= 0.006;女性，RR = 1.52，95% CI = 1.12至2.05; P趋势= 0.002）和身高（男性，RR = 1.40，95% CI = 0.99至1.98; P趋势= 0.04;女性，RR = 1.79，95% CI = 1.30 - 2.46; P趋势
Background: Body weight and body mass index (BMI) are positively related to risk of colon cancer in men, whereas weak or no associations exist in women. This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women. Methods: We used multivariable adjusted Cox proportional hazards models to examine the association between anthropometric measures and risks of colon and rectal cancer among 368 277 men and women who were free of cancer at baseline from nine countries of the European Prospective Investigation Into Cancer and Nutrition. All statistical tests were two-sided. Results: During 6.1 years of follow-up, we identified 984 and 586 patients with colon and rectal cancer, respectively. Body weight and BMI were statistically significantly associated with colon cancer risk in men (highest versus lowest quintile of BMI, relative risk [RR] = 1.55, 95% confidence interval [CI] = 1.12 to 2.15; P-trend =.006) but not in women. In contrast, comparisons of the highest to the lowest quintile showed that several anthropometric measures, including waist circumference (men, RR = 1.39,95% CI = 1.01 to 1.93; P-trend = .001; women, RR = 1.48, 95% CI = 1.08 to 2.03; P-trend =.008), waist-to-hip ratio (WHR; men, RR = 1.51, 95% CI = 1.06 to 2.15; P-trend =.006; women, RR = 1.52, 95% CI = 1.12 to 2.05; P-trend =.002), and height (men, RR = 1.40, 95% CI = 0.99 to 1.98; P-trend =.04; women, RR = 1.79, 95% CI = 1.30 to 2.46; P-trend