Familial imprinting determines H-2 selective mating preferences.
Familial imprinting determines H-2 selective mating preferences.
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家族印记决定了 H-2 选择性交配偏好。
DOI：
10.1126/science.3375818
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Boyse,EA
中科院分区：
文献类型：
--
作者：
Yamazaki,K;Beauchamp,GK;Kupniewski,D;Bard,J;Thomas,L;Boyse,EA
近亲繁殖的雄性小鼠通常喜欢与不同的非自体H-2单倍型的雌性小鼠交配。为了确定这种自然偏好是不可撤销的还是来自家族印记的结果，使用了一个测试系统，该系统依赖于先前的观察结果，即B6雄性（H-2b）优先与同类B6-H-2k而不是B6雌性交配，B6-H-2k雄性与B6雌性交配。这种偏好在B6-H-2k父母养育的B6雄性和B6父母养育的B6-H-2k雄性中被逆转，在这些情况下偏好相同的H-2类型。因此，H-2选择性交配偏好是通过家族H-2类型的印记获得的。
Inbred male mice typically prefer to mate with females of a different, non-self H-2 haplotype. To determine whether this natural preference is irrevocable or results from familial imprinting, a test system was used which relied on previous observations that B6 males (H-2b) mate preferentially with congenic B6-H-2krather than B6 females, and B6-H-2kmales with B6 females. This preference was reversed in B6 males fostered by B6-H-2kparents and in B6-H-2kmales fostered by B6 parents, preference in these cases favoring the same H-2 type. Thus, H-2 selective mating preference is acquired by imprinting on familial H-2 types.