Physiology and Pathophysiology of Selectins, Integrins, and IgSF Cell Adhesion Molecules Focusing on Inflammation. A Paradigm Model on Infectious Endocarditis
Physiology and Pathophysiology of Selectins, Integrins, and IgSF Cell Adhesion Molecules Focusing on Inflammation. A Paradigm Model on Infectious Endocarditis
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DOI：
10.3109/15419061.2011.606381
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发表时间：
2011-06-01
影响因子：
--
通讯作者：
Charalabopoulos, Konstantinos
中科院分区：
文献类型：
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作者：
Golias, Christos;Batistatou, Anna;Charalabopoulos, Konstantinos
无论是在细胞之间还是在细胞与细胞外基质组分之间，粘附键的形成都是一个至关重要的过程。这些相互作用由统称为粘附分子（CAM）的一些分子介导。CAM是广泛表达的蛋白质，在控制细胞迁移、增殖、存活和凋亡中起核心作用。除了它们在生理上维持组织完整性的关键功能之外，CAM在各种病理过程中起着突出的作用，例如心血管疾病、动脉粥样硬化形成、动脉粥样硬化斑块进展和炎症反应的调节。CAM如选择素、整合素和免疫球蛋白超家族参与白细胞与血管内皮之间的相互作用（白细胞滚动、停滞、牢固粘附、迁移）。实验数据和病理学观察支持病原微生物附着于血管内皮细胞或血管损伤部位引发血管内感染的假设。在这篇综述中，重点介绍了细胞粘附分子、病理生理学和感染性心内膜炎的发展。
The development of adhesion bonds, either among cells or among cells and components of the extracellular matrix, is a crucial process. These interactions are mediated by some molecules collectively known as adhesion molecules (CAMs). CAMs are ubiquitously expressed proteins playing a central role in controlling cell migration, proliferation, survival, and apoptosis. Besides their key function in physiological maintenance of tissue integrity, CAMs play an eminent role in various pathological processes such as cardiovascular disorders, atherogenesis, atherosclerotic plaque progression and regulation of the inflammatory response. CAMs such as selectins, integrins, and immunoglobulin superfamily take part in interactions between leukocyte and vascular endothelium (leukocyte rolling, arrest, firm adhesion, migration). Experimental data and pathologic observations support the assumption that pathogenic microorganisms attach to vascular endothelial cells or sites of vascular injury initiating intravascular infections. In this review a paradigm focusing on cell adhesion molecules pathophysiology and infective endocarditis development is given.