Developmental trajectories of overweight during childhood: Role of early life factors
Developmental trajectories of overweight during childhood: Role of early life factors
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DOI：
10.1038/oby.2007.585
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发表时间：
2007-03-01
期刊：
影响因子：
6.9
通讯作者：
Ahluwalia, Jasjit S.
中科院分区：
文献类型：
--
作者：
Li, Chaoyang;Goran, Michael I.;Ahluwalia, Jasjit S.
目的：我们的目标是确定儿童超重的发展轨迹，并评估早期生活对这些轨迹的影响。研究方法和程序：参与者包括1739名2岁以下的白人、黑人和西班牙裔儿童，他们在第一次调查中接受了12岁的跟踪调查。结果：发现了三种不同的超重轨迹：1)早发性超重(10.9%)，2)迟发性超重(5.2%)，3)从不超重(83.9%)。在调整了多个潜在危险因素后，男性[优势比(OR)1.5；95%可信区间(CI)，1.0~2.2]、黑人(OR，1.7；95%CI，1.1~2.6)、母亲25=20.43 kg(OR，1.7；95%CI，1.0~2.9)和出生体重=4000 g(OR，2.0；95%CI，1.2~3.4)与早发超重的风险增加有关。除母亲体重增加外，这些危险因素对迟发性超重也有类似的影响。此外，母亲吸烟(OR，1.6；95%CI，0.8至3.1)和出生顺序：3(OR，2.3；95%CI，1.0至5.2)仅与晚发超重风险增加有关。母乳喂养<4个月与早期超重(OR，0.7；95%CI，0.3~1.3)和晚发型超重(OR，0.7；95%CI，0.3~1.7)的风险降低有关。早期生活预测指标可能会对儿童超重的发展轨迹产生重大影响。
Objective: Our goal was to identify developmental trajectories of overweight in children and to assess early life influences on these trajectories.Research Methods and Procedures: Participants consisted of 1739 white, black, and Hispanic children who were younger than 2 years at the first survey and were followed up to 12 years of age. Repeated measures of overweight, defined as BMI >= 95th percentile, were used to identify overweight trajectories with a latent growth mixture modeling approach.Results: Three distinct overweight trajectories were identified: 1) early onset overweight (10.9%), 2) late onset overweight (5.2%), and 3) never overweight (83.9%). After adjustment for multiple potential risk factors, male gender [odds ratio (OR), 1.5; 95% confidence interval (CI), 1.0 to 2.2], black ethnicity (OR, 1.7; 95% Cl, 1.1 to 2.6), maternal 25 = 20.43 kg (OR, 1.7; 95% Cl, 1.0 to 2.9) and birth weight >= 4000 g (OR, 2.0; 95% Cl, 1.2 to 3.4 were associated with an increased risk of early onset over-weight. These risk factors, except maternal weight gain, exerted similar effects on late onset overweight. In addition, maternal smoking (OR, 1.6; 95% Cl, 0.8 to 3.1) and birth order :3 (OR, 2.3; 95% Cl, 1.0 to 5.2) were associated with an increased risk of late onset overweight only. Breastfeeding >= 4 months was associated with a decreased risk of both early (OR, 0.7; 95% Cl, 0.3 to 1.3) and late onset overweight (OR, 0.7; 95% Cl, 0.3 to 1.7).Discussion: Two trajectories of overweight and one never overweight group were identified. Early life predictors may have a significant influence on the developmental trajectories of overweight in children.