Sorption of norfloxacin in soils: analytical method, kinetics and Freundlich isotherms.
Sorption of norfloxacin in soils: analytical method, kinetics and Freundlich isotherms.
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DOI：
10.1016/j.chemosphere.2014.06.008
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发表时间：
2015
期刊：
影响因子：
8.8
通讯作者：
L. M. Peruchi;A. Fostier;S. Rath
中科院分区：
文献类型：
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作者：
L. M. Peruchi;A. Fostier;S. Rath
氟喹诺酮类药物是一种有效的抗菌剂，对多种病原菌具有很强的抗菌活性，广泛应用于兽医领域。氟喹诺酮类药物及其代谢物可通过动物排泄物或粪便进入土壤，并可能污染水和土壤。这些抗菌剂在土壤上的吸附程度差异很大，这些药物的流动性也是如此。采用间歇平衡实验研究了诺氟沙星在S保罗州四种土壤中的吸附行为。证实了诺氟沙星在色谱测定中存在较强的基质效应。吸附动力学符合拟二级模型(r>；0.99)，吸附/解吸等温线符合对数形式的Freundlich模型(r>；(0.97))。诺氟沙星对土壤颗粒具有较高的亲和力，KF值在643~2410gμG1−1/n(cm~3)1/ng−1之间，KF解吸值在686~2468gμG1−1/n(cm~3)1/ng−~1之间。
Fluoroquinolones are potent antibacterial agents that are active against a wide range of pathogenic organisms and are widely used in veterinary medicine. Fluoroquinolones and their metabolites may reach the soil through animal excreta or manure and may contaminate water and soils. The degree of sorption of these antimicrobials to soils varies widely, as does the mobility of these drugs. In the present study, sorption of norfloxacin in four soils of the state of São Paulo was investigated with batch equilibrium experiments. A strong matrix effect on the chromatographic determination of norfloxacin was verified. Sorption kinetics were best fit by a pseudo second-order model (r> 0.99), and sorption/desorption isotherms were well fit by the Freundlich model in log form (r> 0.97). Norfloxacin showed high affinity for soil particles, withKFsorption values ranging from 643 to 2410 μg1−1/n(cm3)1/ng−1andKFdesorption values ranging from 686 to 2468 μg1−1/n(cm3)1/ng−1. The high desorptionKFvalues indicate that norfloxacin is highly immobile in the evaluated soils.