A bicyclic cispentacin derivative as a novel reverse turn inducer in a GnRH mimetic.
A bicyclic cispentacin derivative as a novel reverse turn inducer in a GnRH mimetic.
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一种双环顺喷他星衍生物，作为 GnRH 模拟物中的新型回转诱导剂。
DOI：
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发表时间：
2002
影响因子：
3.6
通讯作者：
J. Mulzer
中科院分区：
文献类型：
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作者：
Ol Y Langer;H. Kählig;K. Zierler;J. Bats;J. Mulzer
合成了顺喷他星衍生的双环 β-氨基酸 (Bic)，并将其掺入 GnRH 的 6 位。新的 GnRH 类似物的特征在于其在溶液中的结构及其对人类 GnRH 受体的活性和亲和力。
A cispentacin-derived bicyclic beta-amino acid (Bic) has been synthesized and incorporated into the 6-position of GnRH. The new GnRH analogue has been characterized with respect to its structure in solution and its activity and affinity toward the human GnRH receptor.