Platelets and von Willebrand factor
Platelets and von Willebrand factor
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DOI：
10.1016/s1473-0502(03)00046-6
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发表时间：
2003-06-01
影响因子：
1.9
通讯作者：
Freedman, J
中科院分区：
文献类型：
--
作者：
Schmugge, M;Rand, ML;Freedman, J
血小板与血管性血友病因子 (VWF) 的相互作用对于任何止血或血栓形成过程的启动至关重要。 VWF 使血小板通过其表面糖蛋白受体粘附到暴露的内皮下层并对血液中的剪切应力做出反应。通过血小板α颗粒和内皮细胞Weibel-Palade小体储存和释放的VWF，止血系统可以对血管壁病变进行局部反应，并可以启动其他血小板的激活。本综述描述了 VWF 的分子结构、其功能及其与血小板膜糖蛋白受体 GP Ib-IX-V 和 GP IIb-IIIa 的相互作用。此外，还描述了 VWF 在剪切诱导的血小板粘附和聚集中的作用，并讨论了控制 VWF 多聚体大小和血小板对多聚 VWF 反应性的机制。最后，该综述讨论了血小板 α 颗粒和 Weibel-Palade 小体局部释放的 VWF 对新生儿和成人血小板活化的作用。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
The interaction of platelets with von Willebrand factor (VWF) is crucial in the initiation of any hemostatic or thrombotic process. VWF enables the platelet, via its surface glycoprotein receptors, to adhere to exposed subendothelium and to respond to shear stress in the blood. Via VWF that is stored and released from platelet alpha-granules and from Weibel-Palade bodies of endothelial cells, the hemostatic system can respond locally to lesions in the vessel wall and can initiate the activation of other platelets. This review describes the molecular structure of VWF, its functions and its interactions with the platelet membrane glycoprotein receptors GP Ib-IX-V and GP IIb-IIIa. As well, the role of VWF in shear-induced platelet adhesion and aggregation is described, and mechanisms are discussed that control the size of VWF multimers and the responsiveness of platelets to multimeric VWF. Finally, the review discusses the role of locally released VWF from platelet alpha-granules and from Weibel-Palade bodies for platelet activation in neonates and adults. (C) 2003 Elsevier Science Ltd. All rights reserved.