Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation.
Low Serum Oxytocin Concentrations Are Associated with Painful Menstruation.
复制标题
低血清催产素浓度与月经痛有关。
DOI：
10.1007/s43032-019-00071-y
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hellman,KevinM
中科院分区：
文献类型：
--
作者：
Oladosu,FolabomiA;Tu,FrankF;Garfield,LindseyB;Garrison,EllenF;Steiner,NicoleD;Roth,GenevieveE;Hellman,KevinM
催产素依赖性机制被假设为导致月经疼痛，但催产素拮抗剂治疗痛经的临床试验结果不一。相反，更广泛的研究表明，全身催产素浓度的增加与疼痛耐受性的增加和心理社会功能的改善有关。我们试图证实血清催产素浓度的增加是否与月经疼痛和其他心理社会因素有关。有原发性痛经史的女性（n= 19），继发性痛经史的女性（n= 12），以及健康对照组（n= 15）完成了疼痛和心理社会问卷，提供了病史，并对月经前48小时的疼痛进行了评分。在月经期间收集血清样品以测量催产素浓度。与健康对照组（967 ± 53 pg/mL）相比，有原发性（704 ± 33 pg/mL;p< 0.001）或继发性（711 ± 66 pg/mL;p< 0.01）痛经史的参与者的催产素显著较低。过去3个月（r=-0.58;p< 0.001）和研究访视期间（r=-0.45;p= 0.002）的月经疼痛与催产素浓度呈负相关。疼痛灾难化（r=-0.39）、疼痛行为（r=-0.32）和疼痛干扰（r=-0.31）也与催产素水平呈负相关（p < 0.05）。催产素与心理社会因素无显著相关。与我们的假设相反，与健康对照组相比，有原发性或继发性痛经史的女性在月经期间的催产素浓度较低。较低的循环催产素浓度也与更严重的月经疼痛和疼痛相关行为有关。当考虑到现有的文献，低循环催产素可能是一个功能失调的内源性疼痛调制的迹象。
Oxytocin-dependent mechanisms are hypothesized to contribute to painful menses, but clinical trials of oxytocin antagonists for dysmenorrhea have had divergent outcomes. In contrast, broader studies have shown that increased systemic oxytocin concentrations are associated with increased pain tolerance and improved psychosocial function. We sought to confirm whether increased serum oxytocin concentrations are associated with menstrual pain and other psychosocial factors. Women with a history of primary dysmenorrhea (n= 19), secondary dysmenorrhea (n= 12), and healthy controls (n= 15) completed pain and psychosocial questionnaires, provided a medical history, and rated their pain during the first 48 h of menses. Serum samples were collected during menses to measure oxytocin concentrations. Oxytocin was significantly lower in participants with a history of primary (704 ± 33 pg/mL;p< 0.001) or secondary (711 ± 66 pg/mL;p< 0.01) dysmenorrhea compared to healthy controls (967 ± 53 pg/mL). Menstrual pain over the past 3 months (r= −0.58;p< 0.001) and during the study visit (r= −0.45;p= 0.002) was negatively correlated with oxytocin concentrations. Pain catastrophizing (r= −0.39), pain behavior (r= −0.32), and pain interference (r= −0.31) were also negatively correlated with oxytocin levels (p’s < 0.05). Oxytocin was not significantly correlated with psychosocial factors. Contrary to our hypothesis, women with a history of primary or secondary dysmenorrhea had lower oxytocin concentrations during menses when compared to healthy controls. Lower circulating oxytocin concentrations were also associated with worse menstrual pain and pain-related behavior. When considering the existing literature, low circulating oxytocin may be a sign of dysfunctional endogenous pain modulation.