MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations
MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations
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DOI：
10.1016/j.mito.2010.09.013
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发表时间：
2011-03-01
期刊：
影响因子：
4.4
通讯作者：
Yao, Yong-Gang
中科院分区：
文献类型：
--
作者：
Fan, Long;Yao, Yong-Gang
MitoTool是一个基于网络的生物信息学平台，旨在以批处理模式破译人类线粒体DNA（mtDNA）数据。该平台具有以下优势：（i）解析不同类型的mtDNA数据;（ii）根据mtDNA序列或变体自动分类单倍型群;（iii）发现声称具有单倍型群状态的样本中可能缺失的变体;（iv）估计某些替换的进化保守指数、蛋白质编码效应和潜在致病性;（iv）分析可能的突变。（v）对病例组和对照组之间的单倍型群分布频率进行统计分析。此外，它还提供了一个综合数据库，用于检索五种与电子邮件有关的信息。线粒体工具可在http://www.mitotool.org上免费获取。（C）2010 Elsevier B. V.和线粒体研究学会。All rights reserved.
MitoTool, a web-based bioinformatics platform, is designed for deciphering human mitochondrial DNA (mtDNA) data in batch mode. The platform has advantages in (i) parsing diverse types of mtDNA data; (ii) automatically classifying haplogroup according to mtDNA sequences or variants; (iii) discovering possibly missing variants of the samples with claimed haplogroups status; (iv) estimating the evolutionary conservation index, protein coding effect and potential pathogenicity of certain substitutions; (v) performing statistical analysis for haplogroup distribution frequency between case and control groups. Furthermore, it offers an integrated database for retrieving five types of mitochondrion-related information. The MitoTool is freely accessed at http://www.mitotool.org. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.