Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions.
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions.
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DOI：
10.1038/nrmicro3525
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Kuehn MJ
中科院分区：
文献类型：
--
作者：
Schwechheimer C;Kuehn MJ
外膜囊泡（OMV）是由革兰氏阴性菌产生的充满周质内容物的外膜球形芽。OMV的产生允许细菌与其环境相互作用，并且已经发现OMV介导多种功能，包括促进发病机制，使细菌在应激条件下存活以及调节细菌群落内的微生物相互作用。此外，由于这种功能的多功能性，研究人员已经开始探索OMV作为生物工程应用的平台。在这篇综述中，我们讨论了OMV研究的最新进展，重点是对这些囊泡的生物发生机制和功能的新见解。
Outer-membrane vesicles (OMVs) are spherical buds of the outer membrane filled with periplasmic content and are commonly produced by Gram-negative bacteria. The production of OMVs allows bacteria to interact with their environment, and OMVs have been found to mediate diverse functions, including promoting pathogenesis, enabling bacterial survival during stress conditions and regulating microbial interactions within bacterial communities. Additionally, because of this functional versatility, researchers have begun to explore OMVs as a platform for bioengineering applications. In this Review, we discuss recent advances in the study of OMVs, focusing on new insights into the mechanisms of biogenesis and the functions of these vesicles.