Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.
Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.
复制标题
随着年龄的增长，血压对膳食钠和钾的敏感性增加。
DOI：
10.1093/ajh/3.6.505
复制
发表时间：
1990
影响因子：
3.2
通讯作者：
Barrett-Connor,E
中科院分区：
文献类型：
--
作者：
Khaw,KT;Barrett-Connor,E
在南加州40至89岁的887名男性和1159名女性人口中，年龄调整后的收缩压和舒张压与根据随意尿样估计的钠/钾比率显著相关。这种关系在血压和尿液电解质排泄量的整个范围内都很明显。男性和女性的血压存在明显的年龄梯度，血压与钠/钾比率的回归斜率随着年龄的增长而变得更加陡峭。回归斜率总体上约为4毫米汞收缩压和1毫米汞舒张压每单位钠/钾比增加。不应该过早地放弃使用随意的尿样来评估血压和钠/钾关系。这项研究和其他研究的证据表明，人群中血压和电解质摄入量之间的关系可能比之前认为的更动态，在老年人中也更明显，他们患心血管疾病的风险最大。减少与年龄相关的血压升高对预防心血管疾病有相当大的影响。Am J Hyper-ten 1990；3：505-511
In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrolyte excretions. An age gradient was apparent for systolic pressure in both men and women, the regression slope for blood pressure versus sodium/potassium ratio being steeper with increasing age. The regression slope overall was approximately 4 mm Hg systolic and 1 mm Hg diastolic pressure increase per unit increase in sodium/potassium (mmol/mmol) ratio.The use of casual urine samples in assessing the blood pressure and sodium/potassium relationship should not be prematurely dismissed. Evidence from this and other studies suggests the relationship between blood pressure and electrolyte intake in the population may be more dynamic than previously believed, and also more marked in the old, who are at the greatest risk for cardiovascular disease. A reduction in the age-related increase in blood pressure has considerable implications for the prevention of cardiovascular disease. Am J Hyper-tens 1990;3:505-511