Effects of exposure to fluoro-edenite fibre pollution on the respiratory system: an in vivo model.
Effects of exposure to fluoro-edenite fibre pollution on the respiratory system: an in vivo model.
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暴露于氟伊甸岩纤维污染对呼吸系统的影响：体内模型。
DOI：
--
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发表时间：
2006
影响因子：
2
通讯作者：
M. Carnazza
中科院分区：
文献类型：
--
作者：
G. Martinez;Carla Loreto;V. Rapisarda;G. Masumeci;Matteo Valentino;M. Carnazza
An increased standardised rate of mortality from pleural mesothelioma among the population of Biancavilla (Sicily, Italy) has been attributed to exposure to fluoro-edenite fibres. Our aim was to establish whether and how these fibres may induce pathological effects using an in vivo model. Lung tissue collected from 60 healthy sheep selected from six flocks habitually grazing near Biancavilla and from 10 control sheep was fixed formalin and paraffin-embedded; sections were stained with haematoxylin-eosin, Masson trichrome and Gomori argentic impregnation. Histochemical studies and immunohistochemical analysis for the localisation of TRAIL, DR5 and MMP13 were also performed. The lungs of exposed sheep exhibited fibrosis and loss of alveolar architecture with honeycombing of alveolar cavities. Fluoro-edenite fibres were detected close to the alveolar epithelium and interstitia. The parenchyma showed hyaline degeneration and strong PAS-positivity in the interstitium, proteoglycan alterations, reflecting a damaged basal membrane and an involvement of the interstitial matrix. MMP-13 was overexpressed, mainly in fibroblasts and epithelial cells, while positivity for TRAIL and DR5 was detected on alveolar surfaces and in the vascular stroma. The initial pathological event seems to involve first the alveoli and subsequently the interstitium, giving rise to classic honeycombing. The triggering event at the level of type I pneumocytes would damage the cytoplasmic membrane resulting in loss of cell elements and exposure of underlying capillaries, and eventually in a series of reactions including macrophage activation, possible release of growth factors and metaplasic reconstruction of lung alveoli. Immunopositivity for TRAIL and MMP-13 receptor suggests that apoptotic processes may also be activated by fluoro-edenite.
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DOI：
10.1164/arrd.1985.131.2.281
发表时间：
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期刊：
The American review of respiratory disease
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
1998-12-01
影响因子：
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DOI：
10.1152/ajplung.1995.269.6.l819
发表时间：
1995-12-01
影响因子：
4.9
作者：
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