CELLULAR PEPTIDE COMPOSITION GOVERNED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES
CELLULAR PEPTIDE COMPOSITION GOVERNED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES
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DOI：
10.1038/348248a0
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发表时间：
1990-11-15
期刊：
影响因子：
64.8
通讯作者：
RAMMENSEE, HG
中科院分区：
文献类型：
--
作者：
FALK, K;ROTZSCHKE, O;RAMMENSEE, HG
主要的组织相容性复合体（MHC）I类分子将源自细胞蛋白的肽呈递给细胞毒性T淋巴细胞（CTL）1-5，其检查这些肽的异常特征。这些肽在细胞中是如何产生的尚不清楚。在这里，我们表明，MHC分子本身基本上参与确定哪些肽发生在细胞内：正常小鼠脾细胞相同的所有基因，但MHC I类表达不同的模式的肽来自细胞的非MHC蛋白。我们提出了几种模型来解释这种影响的MHC I类分子的细胞肽组成。
MAJOR histocompatibility complex (MHC) class I molecules present peptides derived from cellular proteins to cytotoxic T lymphocytes (CTLs)1–5, which check these peptides for abnormal features. How such peptides arise in the cell is not known. Here we show that the MHC molecules themselves are substantially involved in determining which peptides occur intracellularly: normal mouse spleen cells identical at all genes but MHC class I express different patterns of peptides derived from cellular non-MHC proteins. We suggest several models to explain this influence of MHC class I molecules on cellular peptide composition.