STATISTICAL-METHODS FOR MODEL DISCRIMINATION - APPLICATIONS TO GATING KINETICS AND PERMEATION OF THE ACETYLCHOLINE-RECEPTOR CHANNEL
STATISTICAL-METHODS FOR MODEL DISCRIMINATION - APPLICATIONS TO GATING KINETICS AND PERMEATION OF THE ACETYLCHOLINE-RECEPTOR CHANNEL
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DOI：
10.1016/s0006-3495(87)83331-3
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发表时间：
1987-02-01
影响因子：
3.4
通讯作者：
HORN, R
中科院分区：
文献类型：
--
作者：
HORN, R
描述了判别单个离子通道的门控动力学和渗透性的方法。讨论了最大似然法和回归法。在模型嵌套的简单情况下，可以使用标准假设检验。然而，更常见的是非嵌套模型，并描述了在这些情况下进行模型区分的几种程序，包括允许在选择的显著水平上比较模型的蒙特卡罗方法。作为说明，这些方法被应用于来自乙酰胆碱受体通道的单通道数据。
Methods are described for discrimination of the gating kinetics and permeation of single ionic channels. Both maximum likelihood and regression procedures are discussed. In simple situations, where models are nested, standard hypothesis tests can be used. More commonly, however, non-nested models are of interest, and several procedures are described for model discrimination in these cases, including Monte Carlo methods, which allow the comparison of models at significance levels of choice. As an illustration, the methods are applied to single-channel data from acetycholine receptor channels.