Minimum information requested in the annotation of biochemical models (MIRIAM)
Minimum information requested in the annotation of biochemical models (MIRIAM)
复制标题
DOI：
10.1038/nbt1156
复制
发表时间：
2005-12-01
影响因子：
46.9
通讯作者：
Wanner, BL
中科院分区：
文献类型：
--
作者：
Le Novère, N;Finney, A;Wanner, BL
社区中大多数已发表的定量模型都丢失了，因为它们要么没有可用，要么没有足够的特征以使其被重复使用。缺乏标准描述格式，缺乏严格的审查和作者的粗心性是模型描述不完整的主要原因。随着当今对详细生化模型的兴趣增加，有必要为这些模型的编码定义最低质量标准。我们提出了一组策划生物系统定量模型的规则。这些规则定义了以机器可读形式表示的编码和注释模型的过程。我们认为他们的应用程序将使用户能够（i）有信心，策划模型是其相关参考描述的准确反映，（ii）精确的搜索模型的搜索收集，（iii）迅速确定给定策划模型的生物学现象或模型成分代表并（iv）促进模型的重复使用和组成，并将其组成到大型亚细胞模型中。
Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the main causes for incomplete model descriptions. With today's increased interest in detailed biochemical models, it is necessary to define a minimum quality standard for the encoding of those models. We propose a set of rules for curating quantitative models of biological systems. These rules define procedures for encoding and annotating models represented in machine-readable form. We believe their application will enable users to (i) have confidence that curated models are an accurate reflection of their associated reference descriptions, (ii) search collections of curated models with precision, (iii) quickly identify the biological phenomena that a given curated model or model constituent represents and (iv) facilitate model reuse and composition into large subcellular models.