FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus.
FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus.
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FV-4：影响弗兰德白血病病毒诱导脾肿大的新基因。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
S. Suzuki
中科院分区：
文献类型：
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作者：
S. Suzuki
对 Friend 白血病病毒 (FLV) 抗性新小鼠品系 G 和 DBA/S 小鼠交配的后代进行分析，证实存在 G 对 FLV 抗性的单一显性基因。在这些后代中，没有观察到 FLV 抗性与毛发颜色基因（b、d 和 c）之间的相关性。在((G X BALB/c) X DBA/2)交配的后代中，抗性基因独立于Fv-1分离。 G 小鼠中 Fv-1 基因座上的等位基因似乎对 N-tropic 病毒是允许的。因此，排除了 G 小鼠中 Fv-1b 的并发性。这些结果表明新系小鼠的抗性基因与Fv-1和Fv-2不同。
Analysis of offsprings from mating of a Friend leukemia virus (FLV) resistant new mouse line, G, and DBA/S mice confirmed the existence of a single dominant gene for the resistance of G to FLV. In these offsprings, no correlation between resistance to FLV and hair-color genes (b, d and c) were observed. In the progeny of ((G X BALB/c) X DBA/2) mating, the resistance gene seregated independently from Fv-1. The allele(s) on Fv-1 locus in G mice seemed to be permissive to N-tropic virus. Therefore, conconmitance of Fv-1b in G mice was excluded. These results indicated that the resistance gene in the new line mice differ from Fv-1 and Fv-2.