Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
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DOI：
10.1021/np500412f
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发表时间：
2014-09
影响因子：
5.1
通讯作者：
Youmin Ying;W. Shan;Z. Zhan
中科院分区：
文献类型：
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作者：
Youmin Ying;W. Shan;Z. Zhan
石杉碱 A (hupA) 通过内生真菌 Ceriporia lacerate HS-ZJUT-C13A 进行生物转化，得到化合物 1-5 和三种山梨烷倍半萜类化合物 6-8。 Huptremules A-D (1-4) 具有不寻常的倍半萜-生物碱混合结构，整合了真菌代谢物（山松烷倍半萜）和外源底物 (hupA) 的特征。这些结果支持使用真菌内生菌作为天然产物生物转化的生物催化剂，特别是源自宿主植物的天然产物。
Biotransformation of huperzine A (hupA) by a fungal endophyte, Ceriporia lacerate HS-ZJUT-C13A, afforded compounds 1-5 and three tremulane sesquiterpenoids, 6-8. Huptremules A-D (1-4) feature unusual sesquiterpenoid-alkaloid hybrid structures that integrate the characteristics of fungal metabolites (tremulane sesquiterpenoids) and the exogenous substrate (hupA). These results support the use of fungal endophytes as biocatalysts for the biotransformation of natural products, particularly those originating from the host plant.